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TRIML2 tripartite motif family like 2 [ Homo sapiens (human) ]

Gene ID: 205860, updated on 3-Apr-2024

Summary

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Official Symbol
TRIML2provided by HGNC
Official Full Name
tripartite motif family like 2provided by HGNC
Primary source
HGNC:HGNC:26378
See related
Ensembl:ENSG00000179046 MIM:620480; AllianceGenome:HGNC:26378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPRYD6
Summary
This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in placenta (RPKM 2.0) and testis (RPKM 1.2) See more
Orthologs
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Genomic context

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See TRIML2 in Genome Data Viewer
Location:
4q35.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (188091272..188109603, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (191438954..191457289, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189012426..189030757, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900881 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:188894922-188895422 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188916113-188917092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188917093-188918074 Neighboring gene ZFP42 zinc finger protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188942947-188943484 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953065-188953586 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953587-188954108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:188962925-188963778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:189002377-189002958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189021213-189021714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189027714-189028231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189028751-189029269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189029270-189029788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189033421-189033938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189033939-189034456 Neighboring gene uncharacterized LOC107986337 Neighboring gene FAU pseudogene 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:189047967-189049166 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene tripartite motif family like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation. Zhang X, et al. Mol Biol Evol, 2020 Feb 1. PMID 31633784, Free PMC Article
  2. Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population. Kang WS, et al. Neurosci Lett, 2016 Sep 6. PMID 27471163
  3. STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus. Gu F, et al. PLoS Pathog, 2018 Dec. PMID 30532138, Free PMC Article
  4. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Kung CP, et al. Mol Cancer Res, 2015 Feb. PMID 25256710, Free PMC Article
  5. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Feng YC, et al. Nat Commun, 2020 Oct 5. PMID 33020477, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.
    Title: Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.
  2. the degradation of STAT6 is induced and required for the lytic activation of human herpesviruses and is association with the increased ubiquitylated form of TRIML2
    Title: STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus.
  3. Findings indicate that the C allele of two single nucleotide polymorphisms in the tripartite motif family-like 2 (TRIML2) gene was associated with an increased risk of Alzheimer disease (AD). These results suggest that TRIML2 may contribute to AD susceptibility.
    Title: Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population.
  4. Data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress.
    Title: Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25801, FLJ56315, MGC138164, MGC138166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase TRIML2
Names
RING-type E3 ubiquitin transferase TRIML2
SPRY domain-containing protein 6
tripartite motif family-like protein 2
NP_001290348.1
NP_775824.2
XP_011530039.1
XP_011530040.1
XP_011530041.1
XP_047305721.1
XP_047305722.1
XP_047305723.1
XP_054205167.1
XP_054205168.1
XP_054205169.1
XP_054205170.1
XP_054205171.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303419.1 → NP_001290348.1  probable E3 ubiquitin-protein ligase TRIML2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA729485, AC108073, AK300428, BC111959, BC143709, DA666390
    UniProtKB/TrEMBL
    J3KNI5
    Related
    ENSP00000317498.4, ENST00000326754.7
    Conserved Domains (1) summary
    cd13733
    Location:276 → 449
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  2. NM_173553.4 → NP_775824.2  probable E3 ubiquitin-protein ligase TRIML2 isoform 2

    See identical proteins and their annotated locations for NP_775824.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC108073, AK098667, AK300428, BC111959, DA666390, DC382432
    Consensus CDS
    CCDS3850.2
    UniProtKB/Swiss-Prot
    B7Z6J6, Q8N7C3
    UniProtKB/TrEMBL
    A0A804HJA0, J3KNI5
    Related
    ENSP00000507413.1, ENST00000682553.1
    Conserved Domains (3) summary
    COG1196
    Location:57 → 225
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:251 → 424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:16 → 59
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    188091272..188109603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531738.3 → XP_011530040.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    See identical proteins and their annotated locations for XP_011530040.1

    UniProtKB/Swiss-Prot
    B7Z6J6, Q8N7C3
    UniProtKB/TrEMBL
    A0A804HJA0, J3KNI5
    Conserved Domains (3) summary
    COG1196
    Location:57 → 225
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:251 → 424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:16 → 59
    Bbox_SF; B-box-type zinc finger superfamily

  2. XM_047449767.1 → XP_047305723.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X5

  3. XM_011531737.3 → XP_011530039.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    See identical proteins and their annotated locations for XP_011530039.1

    UniProtKB/Swiss-Prot
    B7Z6J6, Q8N7C3
    UniProtKB/TrEMBL
    A0A804HJA0, J3KNI5
    Related
    ENSP00000422581.2, ENST00000512729.5
    Conserved Domains (3) summary
    COG1196
    Location:57 → 225
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:251 → 424
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:16 → 59
    Bbox_SF; B-box-type zinc finger superfamily

  4. XM_011531739.2 → XP_011530041.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

    UniProtKB/TrEMBL
    B7ZLC3
    Conserved Domains (1) summary
    cd13733
    Location:159 → 332
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

  5. XM_047449765.1 → XP_047305721.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

  6. XM_047449766.1 → XP_047305722.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    191438954..191457289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349192.1 → XP_054205167.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    UniProtKB/Swiss-Prot
    B7Z6J6, Q8N7C3
    UniProtKB/TrEMBL
    A0A804HJA0

  2. XM_054349193.1 → XP_054205168.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    UniProtKB/Swiss-Prot
    B7Z6J6, Q8N7C3
    UniProtKB/TrEMBL
    A0A804HJA0

  3. XM_054349194.1 → XP_054205169.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

  4. XM_054349195.1 → XP_054205170.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

  5. XM_054349196.1 → XP_054205171.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N7C3.2 GenPept UniProtKB/Swiss-Prot:Q8N7C3

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