Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc9a1provided by MGI
Official Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1provided by MGI
Primary source: MGI:MGI:102462
See related: Ensembl:ENSMUSG00000028854 AllianceGenome:MGI:102462
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: swe; Apnh; Nhe1; Mir5122; mir-5122
Summary: Enables sodium:proton antiporter activity. Acts upstream of or within several processes, including regulation of pH; response to acidic pH; and sodium ion transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; nervous system; oocyte; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in stomach adult (RPKM 66.6), adrenal adult (RPKM 34.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133097022..133151013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133369711..133423702)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
Title: Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
Deletion of Slc9a1 in Cx3cr1[+] cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk.
Title: Deletion of Slc9a1 in Cx3cr1(+) cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk.
Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.
Title: Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.
Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice.
Title: Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice.
Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells.
Title: Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells.
Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice.
Title: Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice.
Role of Genetic Mutations of the Na(+)/H(+) Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity.
Title: Role of Genetic Mutations of the Na(+)/H(+) Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity.
The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release.
Title: The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release.
NHE1 and carbonic anhydrase II form a metabolon complex, which was exacerbated in diabetic cardiomyopathy myocardium.Increased phosphorylation of the NHE1 cytosolic tail, and this posttranslational modification is accompanied by increased binding of carbonic anhydrase II to NHE1 and increased Na+/H+ exchange activity by NHE1.
Title: Carbonic anhydrase II/sodium-proton exchanger 1 metabolon complex in cardiomyopathy of ob(-/-) type 2 diabetic mice.
NHE1, the dominant acid-export pathway in cardiac myocytes becomes internalized under hypoxia, which leads to a reduction in acid-extrusion capacity.
Title: Recovery from hypoxia-induced internalization of cardiac Na(+) /H (+) exchanger 1 requires an adequate intracellular store of antioxidants.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc9a1 (e-PCR), detects polymorphism
- UniSTS:547363

Slc9a1 (e-PCR), detects polymorphism
- UniSTS:144433

Slc9a1 (e-PCR), detects polymorphism
- UniSTS:144434

U51112 (e-PCR)
- UniSTS:125765

AW554487 (e-PCR)
- UniSTS:179083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ion binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction by cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of cation-transporting ATPase complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
part_of transporter complex	IDA Inferred from Direct Assay more info	PubMed
part_of transporter complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: sodium/hydrogen exchanger 1

Names: NHE-1; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; slow-wave epilepsy; solute carrier family 9, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358455.1 → NP_001345384.1 sodium/hydrogen exchanger 1 isoform 2

Status: VALIDATED

Source sequence(s)

AK150135, AK165501, AL671882, BQ771297, BU056477, CO041694

Conserved Domains (1) summary

TIGR00840
Location:1 → 321

b_cpa1; sodium/hydrogen exchanger 3
NM_016981.3 → NP_058677.1 sodium/hydrogen exchanger 1 isoform 1

See identical proteins and their annotated locations for NP_058677.1

Status: VALIDATED

Source sequence(s)

AK150135, AK165501, AL671882, BU056477, CO041694

Consensus CDS

CCDS38903.1

UniProtKB/Swiss-Prot

Q61165

UniProtKB/TrEMBL

Q3U3A6, Q3UDC9, Q80X31

Related

ENSMUSP00000030669.8, ENSMUST00000030669.8

Conserved Domains (3) summary

TIGR00840
Location:99 → 664

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:109 → 507

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:606 → 704

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

133097022..133151013

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320089.2 → XP_017175578.1 sodium/hydrogen exchanger 1 isoform X2

Conserved Domains (1) summary

TIGR00840
Location:1 → 321

b_cpa1; sodium/hydrogen exchanger 3
XM_006538686.4 → XP_006538749.1 sodium/hydrogen exchanger 1 isoform X1

UniProtKB/TrEMBL

Q80X31

Conserved Domains (1) summary

TIGR00840
Location:25 → 566

b_cpa1; sodium/hydrogen exchanger 3