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Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 [ Mus musculus (house mouse) ]

Gene ID: 20541, updated on 18-Apr-2024

Summary

Official Symbol
Slc8a1provided by MGI
Official Full Name
solute carrier family 8 (sodium/calcium exchanger), member 1provided by MGI
Primary source
MGI:MGI:107956
See related
Ensembl:ENSMUSG00000054640 AllianceGenome:MGI:107956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ncx1; D930008O12Rik
Summary
Enables ankyrin binding activity; calcium:sodium antiporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to caffeine; metal ion transport; and negative regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including embryonic organ development; metal ion transport; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and nose. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 10.8), frontal lobe adult (RPKM 7.0) and 16 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

Location:
17 E3; 17 51.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (81680534..82045816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (81373105..81738387, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33944 Neighboring gene STARR-seq mESC enhancer starr_43340 Neighboring gene STARR-seq mESC enhancer starr_43341 Neighboring gene predicted gene, 53964 Neighboring gene STARR-seq mESC enhancer starr_43343 Neighboring gene STARR-seq mESC enhancer starr_43344 Neighboring gene STARR-seq mESC enhancer starr_43345 Neighboring gene STARR-seq mESC enhancer starr_43346 Neighboring gene STARR-seq mESC enhancer starr_43347 Neighboring gene ribosomal protein L31. pseudogene 25 Neighboring gene SET translocation pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90693

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium:sodium antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium:sodium antiporter activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential TAS
Traceable Author Statement
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion export IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion export ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium ion transport into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell communication by electrical coupling involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to caffeine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell membrane potential TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in relaxation of smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/calcium exchanger 1
Names
Na(+)/Ca(2+)-exchange protein 1
Na/Ca exchanger
solute carrier family 8 member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112798.2NP_001106269.1  sodium/calcium exchanger 1 isoform B precursor

    See identical proteins and their annotated locations for NP_001106269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks two in-frame exons in the coding region, compared to variant A. The resulting isoform (B) lacks two internal segments, compared to isoform A.
    Source sequence(s)
    AC122399, BB660129, BC079673
    Consensus CDS
    CCDS50191.1
    UniProtKB/TrEMBL
    G5E8Y0, Q68FL0
    Related
    ENSMUSP00000157278.2, ENSMUST00000234131.2
    Conserved Domains (1) summary
    TIGR00845
    Location:1958
    caca; sodium/calcium exchanger 1
  2. NM_001286684.1NP_001273613.1  sodium/calcium exchanger 1 isoform C precursor

    See identical proteins and their annotated locations for NP_001273613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) lacks an internal segment in the 3' terminal exon, which results in an alternate stop codon, compared to variant A. The resulting isoform (C) has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC104139, AC122399, AC131656
    Consensus CDS
    CCDS89163.1
    UniProtKB/TrEMBL
    A0A3Q4EBU5, O35157
    Related
    ENSMUSP00000157030.2, ENSMUST00000235015.2
    Conserved Domains (5) summary
    smart00237
    Location:534624
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:1935
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:797928
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:403493
    Calx-beta; Calx-beta domain
    pfam16494
    Location:251381
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain
  3. NM_011406.3NP_035536.2  sodium/calcium exchanger 1 isoform A precursor

    See identical proteins and their annotated locations for NP_035536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AC122399, BB660129, BC079673, U70033
    Consensus CDS
    CCDS37706.1
    UniProtKB/Swiss-Prot
    P70414
    UniProtKB/TrEMBL
    G3X9J1
    Related
    ENSMUSP00000132809.3, ENSMUST00000163123.3
    Conserved Domains (1) summary
    TIGR00845
    Location:1970
    caca; sodium/calcium exchanger 1

RNA

  1. NR_104580.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) differs in several internal exons, compared to variant A. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant A, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104139, AC122399, AC131656

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    81680534..82045816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523933.3XP_006523996.1  sodium/calcium exchanger 1 isoform X1

    See identical proteins and their annotated locations for XP_006523996.1

    UniProtKB/Swiss-Prot
    P70414
    UniProtKB/TrEMBL
    G3X9J1
    Conserved Domains (1) summary
    TIGR00845
    Location:1970
    caca; sodium/calcium exchanger 1
  2. XM_006523944.2XP_006524007.1  sodium/calcium exchanger 1 isoform X12

    UniProtKB/TrEMBL
    G5E8Y0
    Conserved Domains (1) summary
    TIGR00845
    Location:1934
    caca; sodium/calcium exchanger 1
  3. XM_006523940.2XP_006524003.1  sodium/calcium exchanger 1 isoform X8

    UniProtKB/TrEMBL
    G5E8Y0
    Conserved Domains (1) summary
    TIGR00845
    Location:1957
    caca; sodium/calcium exchanger 1
  4. XM_006523938.2XP_006524001.1  sodium/calcium exchanger 1 isoform X6

    UniProtKB/TrEMBL
    G5E8Y0
    Conserved Domains (1) summary
    TIGR00845
    Location:1962
    caca; sodium/calcium exchanger 1
  5. XM_006523942.2XP_006524005.1  sodium/calcium exchanger 1 isoform X10

    UniProtKB/Swiss-Prot
    P70414
    Conserved Domains (1) summary
    TIGR00845
    Location:1941
    caca; sodium/calcium exchanger 1
  6. XM_006523936.2XP_006523999.1  sodium/calcium exchanger 1 isoform X4

    UniProtKB/Swiss-Prot
    P70414
    Conserved Domains (1) summary
    TIGR00845
    Location:1964
    caca; sodium/calcium exchanger 1
  7. XM_006523934.2XP_006523997.1  sodium/calcium exchanger 1 isoform X2

    UniProtKB/Swiss-Prot
    P70414
    Conserved Domains (1) summary
    TIGR00845
    Location:1969
    caca; sodium/calcium exchanger 1
  8. XM_006523943.2XP_006524006.1  sodium/calcium exchanger 1 isoform X11

    UniProtKB/TrEMBL
    G5E8Y0
    Conserved Domains (1) summary
    TIGR00845
    Location:1935
    caca; sodium/calcium exchanger 1
  9. XM_006523939.2XP_006524002.1  sodium/calcium exchanger 1 isoform X7

    See identical proteins and their annotated locations for XP_006524002.1

    UniProtKB/TrEMBL
    G5E8Y0, Q68FL0
    Conserved Domains (1) summary
    TIGR00845
    Location:1958
    caca; sodium/calcium exchanger 1
  10. XM_006523937.2XP_006524000.1  sodium/calcium exchanger 1 isoform X5

    UniProtKB/TrEMBL
    G5E8Y0
    Related
    ENSMUSP00000126373.3, ENSMUST00000163680.9
    Conserved Domains (1) summary
    TIGR00845
    Location:1963
    caca; sodium/calcium exchanger 1
  11. XM_006523941.2XP_006524004.1  sodium/calcium exchanger 1 isoform X9

    UniProtKB/Swiss-Prot
    P70414
    Conserved Domains (1) summary
    TIGR00845
    Location:1942
    caca; sodium/calcium exchanger 1
  12. XM_006523935.2XP_006523998.1  sodium/calcium exchanger 1 isoform X3

    UniProtKB/Swiss-Prot
    P70414
    Conserved Domains (1) summary
    TIGR00845
    Location:1965
    caca; sodium/calcium exchanger 1
  13. XM_006523932.2XP_006523995.1  sodium/calcium exchanger 1 isoform X1

    See identical proteins and their annotated locations for XP_006523995.1

    UniProtKB/Swiss-Prot
    P70414
    UniProtKB/TrEMBL
    G3X9J1
    Conserved Domains (1) summary
    TIGR00845
    Location:1970
    caca; sodium/calcium exchanger 1
  14. XM_017317368.2XP_017172857.1  sodium/calcium exchanger 1 isoform X13

    UniProtKB/TrEMBL
    Q27PY9, Q91ZJ7
    Conserved Domains (1) summary
    TIGR00845
    Location:1639
    caca; sodium/calcium exchanger 1
  15. XM_017317369.2XP_017172858.1  sodium/calcium exchanger 1 isoform X13

    UniProtKB/TrEMBL
    Q27PY9, Q91ZJ7
    Related
    ENSMUSP00000159714.1, ENSMUST00000249357.1
    Conserved Domains (1) summary
    TIGR00845
    Location:1639
    caca; sodium/calcium exchanger 1
  16. XM_017317370.2XP_017172859.1  sodium/calcium exchanger 1 isoform X13

    UniProtKB/TrEMBL
    Q27PY9, Q91ZJ7
    Conserved Domains (1) summary
    TIGR00845
    Location:1639
    caca; sodium/calcium exchanger 1

RNA

  1. XR_004939482.1 RNA Sequence