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Slc4a1ap solute carrier family 4 (anion exchanger), member 1, adaptor protein [ Mus musculus (house mouse) ]

Gene ID: 20534, updated on 21-Apr-2024

Summary

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Official Symbol
Slc4a1approvided by MGI
Official Full Name
solute carrier family 4 (anion exchanger), member 1, adaptor proteinprovided by MGI
Primary source
MGI:MGI:1196608
See related
Ensembl:ENSMUSG00000029141 AllianceGenome:MGI:1196608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kanadaptin
Summary
Predicted to enable mRNA binding activity. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC4A1AP (solute carrier family 4 member 1 adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.3), CNS E14 (RPKM 3.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 17.27 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31684125..31711386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31526781..31561755)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6315 Neighboring gene STARR-seq mESC enhancer starr_12772 Neighboring gene GPN-loop GTPase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31829068-31829342 Neighboring gene SPT7-like, STAGA complex gamma subunit Neighboring gene STARR-seq mESC enhancer starr_12773 Neighboring gene expressed sequence AI839979 Neighboring gene STARR-seq mESC enhancer starr_12777 Neighboring gene predicted gene, 38424 Neighboring gene STARR-positive B cell enhancer ABC_E4750 Neighboring gene mitochondrial ribosomal protein L33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. Chen J, et al. J Biol Chem, 1998 Jan 9. PMID 9422766
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kanadaptin
Names
solute carrier family 4 (anion exchanger), member 1, adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347328.1 → NP_001334257.1  kanadaptin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113276, AC114613
    Consensus CDS
    CCDS84865.1
    UniProtKB/TrEMBL
    E9PX68
    Related
    ENSMUSP00000144257.2, ENSMUST00000202950.4

  2. NM_001359154.1 → NP_001346083.1  kanadaptin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC113276, AC114613
    Conserved Domains (2) summary
    cd00060
    Location:113 → 221
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00035
    Location:316 → 384
    dsrm; Double-stranded RNA binding motif

  3. NM_001359156.1 → NP_001346085.1  kanadaptin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC113276, AC114613
    UniProtKB/TrEMBL
    Q3UUI2
    Conserved Domains (2) summary
    cd00060
    Location:113 → 221
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00035
    Location:316 → 384
    dsrm; Double-stranded RNA binding motif

  4. NM_001359157.1 → NP_001346086.1  kanadaptin isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AC113276, BC072588
    Consensus CDS
    CCDS89902.1
    UniProtKB/TrEMBL
    E9Q1Q0, Q6GQW1
    Related
    ENSMUSP00000143960.2, ENSMUST00000201858.4
    Conserved Domains (2) summary
    cd00060
    Location:113 → 221
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00035
    Location:316 → 384
    dsrm; Double-stranded RNA binding motif

  5. NM_001421405.1 → NP_001408334.1  kanadaptin isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC113276, AC114613

  6. NM_001421406.1 → NP_001408335.1  kanadaptin isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC113276, AC114613

  7. NM_009206.2 → NP_033232.2  kanadaptin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK138398, AK149108, BC090964
    Consensus CDS
    CCDS51460.1
    UniProtKB/TrEMBL
    E9Q585
    Related
    ENSMUSP00000110179.3, ENSMUST00000114533.9
    Conserved Domains (4) summary
    COG1716
    Location:110 → 245
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:113 → 221
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam00035
    Location:316 → 384
    dsrm; Double-stranded RNA binding motif
    pfam04895
    Location:432 → 485
    DUF651; Archaeal protein of unknown function (DUF651)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31684125..31711386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004942464.1 RNA Sequence

  2. XR_004942466.1 RNA Sequence

  3. XR_004942465.1 RNA Sequence

  4. XR_004942467.1 RNA Sequence

  5. XR_004942468.1 RNA Sequence

  6. XR_004942469.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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