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Slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 [ Mus musculus (house mouse) ]

Gene ID: 20523, updated on 11-Apr-2024

Summary

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Official Symbol
Slc25a14provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, brain), member 14provided by MGI
Primary source
MGI:MGI:1330823
See related
Ensembl:ENSMUSG00000031105 AllianceGenome:MGI:1330823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCP5; BMCP1; UCP5L; UCP5S
Summary
Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in anion transport. Located in mitochondrial envelope. Is expressed in nervous system. Orthologous to human SLC25A14 (solute carrier family 25 member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 8.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A5; X 25.69 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47712333..47751171)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48623418..48662298)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47122 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C Neighboring gene G-protein coupled receptor 119 Neighboring gene STARR-seq mESC enhancer starr_47124 Neighboring gene RNA binding motif protein, X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Uncoupling proteins: a complex journey to function discovery. Cioffi F, et al. Biofactors, 2009 Sep-Oct. PMID 19626697
  2. Mitochondrial uncoupling proteins--what is their physiological role? Echtay KS. Free Radic Biol Med, 2007 Nov 15. PMID 17936181
  3. Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge. Kitahara T, et al. Neuroscience, 2005. PMID 16111824
  4. Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle. Lengacher S, et al. J Cereb Blood Flow Metab, 2004 Jul. PMID 15241186
  5. The role of uncoupling proteins in the regulation of metabolism. Erlanson-Albertsson C. Acta Physiol Scand, 2003 Aug. PMID 12864746

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in inorganic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brain mitochondrial carrier protein 1
Names
mitochondrial uncoupling protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166450.4 → NP_001159922.1  brain mitochondrial carrier protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159922.1

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    Consensus CDS
    CCDS53066.1
    UniProtKB/Swiss-Prot
    Q9ESI8, Q9Z2B2
    UniProtKB/TrEMBL
    Q8CJ23
    Related
    ENSMUSP00000110586.2, ENSMUST00000114936.8
    Conserved Domains (2) summary
    PTZ00169
    Location:44 → 323
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:234 → 323
    Mito_carr; Mitochondrial carrier protein

  2. NM_001290703.2 → NP_001277632.1  brain mitochondrial carrier protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001277632.1

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    Consensus CDS
    CCDS72376.1
    UniProtKB/TrEMBL
    A0A0A0MQJ8, Q8CJ24
    Conserved Domains (2) summary
    PTZ00169
    Location:9 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:199 → 288
    Mito_carr; Mitochondrial carrier protein

  3. NM_001290704.2 → NP_001277633.1  brain mitochondrial carrier protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001277633.1

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    Consensus CDS
    CCDS72376.1
    UniProtKB/TrEMBL
    A0A0A0MQJ8, Q8CJ24
    Related
    ENSMUSP00000120332.3, ENSMUST00000134257.8
    Conserved Domains (2) summary
    PTZ00169
    Location:9 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:199 → 288
    Mito_carr; Mitochondrial carrier protein

  4. NM_001290705.2 → NP_001277634.1  brain mitochondrial carrier protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001277634.1

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    Q8CJ24
    Conserved Domains (2) summary
    PTZ00169
    Location:63 → 342
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:253 → 342
    Mito_carr; Mitochondrial carrier protein

  5. NM_001359136.2 → NP_001346065.1  brain mitochondrial carrier protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    Consensus CDS
    CCDS30112.1
    UniProtKB/TrEMBL
    Q8CJ24
    Conserved Domains (2) summary
    PTZ00169
    Location:41 → 320
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:231 → 320
    Mito_carr; Mitochondrial carrier protein

  6. NM_001403250.1 → NP_001390179.1  brain mitochondrial carrier protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/Swiss-Prot
    Q9ESI8, Q9Z2B2

  7. NM_001403251.1 → NP_001390180.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  8. NM_001403252.1 → NP_001390181.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  9. NM_001403254.1 → NP_001390183.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  10. NM_001403256.1 → NP_001390185.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  11. NM_001403258.1 → NP_001390187.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  12. NM_001403259.1 → NP_001390188.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  13. NM_001403260.1 → NP_001390189.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  14. NM_001403261.1 → NP_001390190.1  brain mitochondrial carrier protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    UniProtKB/TrEMBL
    A0A0A0MQJ8

  15. NM_001403262.1 → NP_001390191.1  brain mitochondrial carrier protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042

  16. NM_001403263.1 → NP_001390192.1  brain mitochondrial carrier protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042

  17. NM_001403264.1 → NP_001390193.1  brain mitochondrial carrier protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042

  18. NM_001403265.1 → NP_001390194.1  brain mitochondrial carrier protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042

  19. NM_011398.4 → NP_035528.1  brain mitochondrial carrier protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_035528.1

    Status: VALIDATED

    Source sequence(s)
    AL669901, AL672042
    Consensus CDS
    CCDS30112.1
    UniProtKB/TrEMBL
    Q8CJ24
    Related
    ENSMUSP00000033431.8, ENSMUST00000033431.14
    Conserved Domains (2) summary
    PTZ00169
    Location:41 → 320
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:231 → 320
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47712333..47751171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2B2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2B2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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