Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc23a1provided by MGI
Official Full Name: solute carrier family 23 (nucleobase transporters), member 1provided by MGI
Primary source: MGI:MGI:1341903
See related: Ensembl:ENSMUSG00000024354 AllianceGenome:MGI:1341903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SVCT1; YSPL3; Slc23a2; D18Ucla2
Summary: Enables L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport; brain development; and lung development. Located in basal plasma membrane and cytoplasm. Is expressed in several structures, including alimentary system; liver; and urinary system. Orthologous to human SLC23A1 (solute carrier family 23 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 78.2), liver adult (RPKM 28.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.17 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35747657..35762900, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35604224..35629845, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
Title: Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.
Title: Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations.
Aging modulates vitamin C transporter expression. Renal over-expression of SVCT1 enhances vitamin C reabsorption in aged animals that may synthesize less vitamin C.
Title: Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney.
The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells.
Title: Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development.
a key role for Slc23a1 in renal ascorbate absorption and perinatal survival and reveal regulation of vitamin C biosynthesis in mice.
Title: Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.
By using primary cultured hepatocytes from SMP30/GNL KO mice, we found that SVCT1 and SVCT2 mRNA expression levels and AA uptake ability were significantly enhanced in the hepatocytes of ascorbic acid-depleted SMP30/GNL KO mice.
Title: Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice.
This work describe the molecular identity of the transporters involved in vitamin C transport in Sertoli cells.
Title: Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells.
PPARalpha up-regulates the expression of Slc23a1 in small intestine.
Title: PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine.
SVCT1 is responsible for epidermal ascorbic acid supply, whereas SVCT2 mainly facilitates ascorbic acid transport in the dermal compartment
Title: Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress.
SVCT2 is major determinant of ascorbate accumulation in tissues lacking SVCT1. SVCT isoforms appear to function independently of one another. SVCT1 expression and ascorbate concentrations in SVCT1-predominant organs were not affected by SVCT2 deficiency.
Title: Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

D18SLACGT1 (e-PCR)
- UniSTS:477376

AU045972 (e-PCR)
- UniSTS:160718

Slc23a1 (e-PCR), detects polymorphism
- UniSTS:547024

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-ascorbate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-ascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-ascorbic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 23 member 1

Names: Na(+)/L-ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; solute carrier family 23 (nucleobase transporters), member 2; yolk sac permease-like molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011397.4 → NP_035527.3 solute carrier family 23 member 1

See identical proteins and their annotated locations for NP_035527.3

Status: VALIDATED

Source sequence(s)

AC121821, AK143959

Consensus CDS

CCDS29144.1

UniProtKB/Swiss-Prot

Q3TNA2, Q8C3M2, Q91WR7, Q9Z2J0

Related

ENSMUSP00000025212.6, ENSMUST00000025212.8

Conserved Domains (2) summary

pfam00860
Location:52 → 479

Xan_ur_permease; Permease family

cl23746
Location:35 → 476

HCO3_cotransp; HCO3- transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

35747657..35762900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317851.3 → XP_017173340.2 solute carrier family 23 member 1 isoform X1

Conserved Domains (1) summary

pfam00860
Location:115 → 542

Xan_ur_permease; Permease family