Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc1a5provided by MGI
Official Full Name: solute carrier family 1 (neutral amino acid transporter), member 5provided by MGI
Primary source: MGI:MGI:105305
See related: Ensembl:ENSMUSG00000001918 AllianceGenome:MGI:105305
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1; Slc1a7
Summary: Enables L-aspartate transmembrane transporter activity and neutral amino acid transmembrane transporter activity. Involved in L-aspartate import across plasma membrane and transport across blood-brain barrier. Located in basal plasma membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and respiratory system. Orthologous to human SLC1A5 (solute carrier family 1 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 377.3), mammary gland adult (RPKM 328.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 9.15 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (16515259..16532199)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16781334..16798274)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
Title: Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer.
The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells.
Title: The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells.
LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
Title: LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression.
Title: Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression.
TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
Title: TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
Title: Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells.
SLC1A5 provides glutamine and asparagine necessary for bone development in mice.
Title: SLC1A5 provides glutamine and asparagine necessary for bone development in mice.
Relationships between Slc1a5 and Osteoclastogenesis.
Title: Relationships between Slc1a5 and Osteoclastogenesis.
Studies indicate a mechanism by which transcriptional enhancer factor 1 (TEAD1) promotes vascular smooth muscle cells (VSMCs) proliferation via transcriptional induction of solute carrier family 1 member 5 (SLC1A5).
Title: TEAD1 (TEA Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake.
The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS.
Title: Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235608

BB222471 (e-PCR)
- UniSTS:208071

Slc1a5 (e-PCR), detects polymorphism
- UniSTS:547016

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-aspartate import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-aspartate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in glutamine secretion	ISO Inferred from Sequence Orthology more info
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neutral amino acid transporter B(0)

Names: ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; ATB(0); insulin-activated amino acid transporter; sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 member 5; solute carrier family 1, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009201.2 → NP_033227.2 neutral amino acid transporter B(0)

See identical proteins and their annotated locations for NP_033227.2

Status: VALIDATED

Source sequence(s)

AK148346, AK157838

Consensus CDS

CCDS39785.1

UniProtKB/TrEMBL

Q3UFR4, Q9ESU7

Related

ENSMUSP00000104136.3, ENSMUST00000108496.9

Conserved Domains (1) summary

pfam00375
Location:55 → 496

SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

16515259..16532199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539695.3 → XP_006539758.1 neutral amino acid transporter B(0) isoform X1

Conserved Domains (1) summary

pfam00375
Location:25 → 232

SDF; Sodium:dicarboxylate symporter family