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Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 [ Mus musculus (house mouse) ]

Gene ID: 20502, updated on 21-Apr-2024

Summary

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Official Symbol
Slc16a2provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 2provided by MGI
Primary source
MGI:MGI:1203732
See related
Ensembl:ENSMUSG00000033965 AllianceGenome:MGI:1203732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mct8; Xpct
Summary
Predicted to enable amino acid transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Acts upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Acts upstream of or within thyroid hormone transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; cochlea; and limb. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 54.4), liver adult (RPKM 41.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 46.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102741020..102865594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103697414..103821988, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Ftx transcript, Xist regulator, non-protein coding Neighboring gene STARR-seq mESC enhancer starr_47699 Neighboring gene STARR-positive B cell enhancer ABC_E5733 Neighboring gene predicted gene 9159 Neighboring gene zinc finger, CCHC domain containing 13 Neighboring gene predicted gene 53059 Neighboring gene predicted pseudogene 6222 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations. Valcárcel-Hernández V, et al. Neurobiol Dis, 2022 Nov. PMID 36243247
  2. Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice. Lademann F, et al. Bone, 2022 Jun. PMID 35240348
  3. Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice. Lademann F, et al. Thyroid, 2020 Feb. PMID 31910109
  4. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Johannes J, et al. Endocrinology, 2016 Apr. PMID 26910310
  5. Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. Ohba K, et al. Endocrinology, 2016 Apr. PMID 26866609, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
    Title: Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
  2. The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
    Title: The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
  3. Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.
    Title: Neurovascular unit disruption and blood-brain barrier leakage in MCT8 deficiency.
  4. Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS.
    Title: Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS.
  5. A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations.
    Title: A CRISPR/Cas9-engineered avatar mouse model of monocarboxylate transporter 8 deficiency displays distinct neurological alterations.
  6. Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice.
    Title: Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice.
  7. Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
    Title: Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
  8. Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
    Title: Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
  9. Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice.
    Title: Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice.
  10. Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling.
    Title: Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect thyroid hormone generation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_negative_effect thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 8
Names
MCT 8
Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter)
X-linked PEST-containing transporter
solute carrier family 16 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009197.2 → NP_033223.2  monocarboxylate transporter 8

    See identical proteins and their annotated locations for NP_033223.2

    Status: VALIDATED

    Source sequence(s)
    BC080678, BM935188, CJ177309, CX218841
    Consensus CDS
    CCDS30330.1
    UniProtKB/Swiss-Prot
    O70324, Q8K3S9
    UniProtKB/TrEMBL
    Q05BA2
    Related
    ENSMUSP00000037629.6, ENSMUST00000042664.10
    Conserved Domains (1) summary
    cl26868
    Location:92 → 519
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    102741020..102865594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251272.2 → XP_030107132.1  monocarboxylate transporter 8 isoform X1

    UniProtKB/TrEMBL
    Q8K3S7
    Conserved Domains (1) summary
    cl28910
    Location:32 → 386
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70324.2 GenPept UniProtKB/Swiss-Prot:O70324

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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