Slc10a2 solute carrier family 10, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc10a2provided by MGI
Official Full Name: solute carrier family 10, member 2provided by MGI
Primary source: MGI:MGI:1201406
See related: Ensembl:ENSMUSG00000023073 AllianceGenome:MGI:1201406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ASBT; IBAT; ISBT; 9130221J18Rik
Summary: Predicted to enable bile acid:sodium symporter activity. Acts upstream of or within response to bacterium. Located in apical plasma membrane and microvillus. Is expressed in Peyer's patch; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to human SLC10A2 (solute carrier family 10 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 20.9), kidney adult (RPKM 7.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 2.16 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (5133219..5155287, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (5083219..5105287, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.
Title: Loss of apical sodium bile acid transporter alters bile acid circulation and reduces biliary damage in cholangitis.
Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model.
Title: Integrated plasma and liver gas chromatography mass spectrometry and liquid chromatography mass spectrometry metabolomics to reveal physiological functions of sodium taurocholate cotransporting polypeptide (NTCP) with an Ntcp knockout mouse model.
Study in Diversity Outbred mice identified the ileal bile acid transporter Slc10a2 as a candidate gene that regulates both the abundance of Turicibacter sp. and plasma levels of cholic acid.
Title: Genetic determinants of gut microbiota composition and bile acid profiles in mice.
data support the concept that under physiological conditions microbiota stimulate Gata4, which suppresses Asbt expression
Title: Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.
In Asbt-deficient mice, the lack of bile acid uptake in the distal small intestine, which we recently documented using novel in vivo imaging results in more than 10-fold increased fecal bile acids
Title: Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids.
ileal ASBT protein is degraded by a ubiquitin-dependent pathway in response to enterobacteria-associated bile acids
Title: Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids.
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt(-/-)apoE(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1).
Title: Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice.
The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined.
Title: Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression.
Enterobacteria-mediated bile acid biotransformation modulates intestinal bile acid transport via downregulation of SLC10A2 expression.
Title: Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression.
These data confirm that bile acids and upregulation of ASBT play a crucial role in NEC pathogenesis and suggest that inhibition of ASBT could be utilized as a therapeutic modality against this disease.
Title: Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc10a2 (e-PCR), detects polymorphism
- UniSTS:144408

NoName (e-PCR)
- UniSTS:495403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ileal sodium/bile acid cotransporter

Names: Na(+)-dependent ileal bile acid transporter; apical sodium-dependent bile acid transporter; ileal Na(+)/bile acid cotransporter; ileal sodium-dependent bile acid transporter; sodium/taurocholate cotransporting polypeptide, ileal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.