U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stil Scl/Tal1 interrupting locus [ Mus musculus (house mouse) ]

Gene ID: 20460, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Stilprovided by MGI
Official Full Name
Scl/Tal1 interrupting locusprovided by MGI
Primary source
MGI:MGI:107477
See related
Ensembl:ENSMUSG00000028718 AllianceGenome:MGI:107477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sil
Summary
This gene encodes a centrosomal protein ubiquitously expressed in proliferating cells and during early embryonic development. Mice lacking the encoded protein die in utero with marked growth retardation, defects in the developing neural fold and randomization of left-right asymmetry. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in CNS E11.5 (RPKM 6.3), liver E14 (RPKM 5.4) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D1; 4 52.73 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114857287..114900404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115000108..115043203)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:114620034-114620334 Neighboring gene predicted gene, 40229 Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114672416-114672599 Neighboring gene STARR-seq mESC enhancer starr_11107 Neighboring gene predicted gene, 52674 Neighboring gene predicted gene, 33786 Neighboring gene T cell acute lymphocytic leukemia 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lack of centrioles and primary cilia in STIL(-/-) mouse embryos. David A, et al. Cell Cycle, 2014. PMID 25486474, Free PMC Article
  2. Cloning and characterization of the SIL promoter. Colaizzo-Anas T, et al. Biochim Biophys Acta, 2003 Jan 27. PMID 12531481
  3. Expression of the SIL gene is correlated with growth induction and cellular proliferation. Izraeli S, et al. Cell Growth Differ, 1997 Nov. PMID 9372240
  4. Cloning and characterization of a murine SIL gene. Collazo-Garcia N, et al. Genomics, 1995 Dec 10. PMID 8825637
  5. Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Aplan PD, et al. Mol Cell Biol, 1991 Nov. PMID 1922059, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STIL(-/-) mouse embryos do not contain centrioles or primary cilia, suggesting that these organelles are not essential for mammalian development until mid gestation.
    Title: Lack of centrioles and primary cilia in STIL(-/-) mouse embryos.
  2. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
    Title: The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
  3. cloned a mouse homolog of the human SIL promoter
    Title: Cloning and characterization of the SIL promoter.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within centrosome duplication ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within floor plate development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of spindle assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SCL-interrupting locus protein homolog
Names
Tal1 interrupting locus

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304551.1 → NP_001291480.1  SCL-interrupting locus protein homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL670035, BC087545, CJ098395
    UniProtKB/Swiss-Prot
    A2AD39, Q60988, Q80VK7, Q8C7U6, Q8CEL7, Q99KL4
    Conserved Domains (1) summary
    pfam15253
    Location:1 → 200
    STIL_N; SCL-interrupting locus protein N-terminus

  2. NM_001304553.1 → NP_001291482.1  SCL-interrupting locus protein homolog isoform 5

    See identical proteins and their annotated locations for NP_001291482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon and uses a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC060706, CJ098395

  3. NM_001304555.1 → NP_001291484.1  SCL-interrupting locus protein homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC060706, CJ098395
    UniProtKB/Swiss-Prot
    A2AD39, Q60988, Q80VK7, Q8C7U6, Q8CEL7, Q99KL4
    Conserved Domains (1) summary
    pfam15253
    Location:22 → 426
    STIL_N; SCL-interrupting locus protein N-terminus

  4. NM_001304559.1 → NP_001291488.1  SCL-interrupting locus protein homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal in-frame exon compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AK049550, BC060706, CJ098395
    UniProtKB/TrEMBL
    Q8BQI9
    Conserved Domains (1) summary
    pfam15253
    Location:22 → 410
    STIL_N; SCL-interrupting locus protein N-terminus

  5. NM_009185.3 → NP_033211.2  SCL-interrupting locus protein homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK019471, AK049223, BC060706, CJ098467
    Consensus CDS
    CCDS18485.1
    UniProtKB/Swiss-Prot
    A2AD39, Q60988, Q80VK7, Q8C7U6, Q8CEL7, Q99KL4
    Related
    ENSMUSP00000030490.7, ENSMUST00000030490.13
    Conserved Domains (1) summary
    pfam15253
    Location:22 → 426
    STIL_N; SCL-interrupting locus protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    114857287..114900404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320088.2 → XP_017175577.1  SCL-interrupting locus protein homolog isoform X1

    UniProtKB/Swiss-Prot
    A2AD39, Q60988, Q80VK7, Q8C7U6, Q8CEL7, Q99KL4
    Conserved Domains (1) summary
    pfam15253
    Location:22 → 398
    STIL_N; SCL-interrupting locus protein N-terminus

  2. XM_030253376.2 → XP_030109236.1  SCL-interrupting locus protein homolog isoform X2

    Conserved Domains (1) summary
    pfam15253
    Location:1 → 155
    STIL_N; SCL-interrupting locus protein N-terminus

RNA

  1. XR_004941856.1 RNA Sequence

    Related
    ENSMUST00000141933.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60988.2 GenPept UniProtKB/Swiss-Prot:Q60988

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous