Format

Send to:

Choose Destination

St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20451, updated on 20-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
St8sia3provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:106019
See related
Ensembl:ENSMUSG00000056812 AllianceGenome:MGI:106019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat8c; ST8SiaIII
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and protein sialylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain and testis. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 10.9), CNS E18 (RPKM 10.3) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 E1; 18 37.25 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64387430..64409217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64254359..64276146)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene peroxiredoxin 1, pseudogene 1 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_44803 Neighboring gene one cut domain, family member 2 Neighboring gene STARR-seq mESC enhancer starr_44804 Neighboring gene STARR-seq mESC enhancer starr_44805

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D(2) and adenosine A(2A) receptors. Lin CY, et al. Transl Psychiatry, 2019 Aug 27. PMID 31455764, Free PMC Article
  2. Differential expression of disialic acids in the cerebellum of senile mice. Rinflerch AR, et al. Glycobiology, 2012 Mar. PMID 22038478
  3. Unique genomic structure and expression of the mouse alpha 2,8-sialyltransferase (ST8Sia III) gene. Yoshida Y, et al. Glycobiology, 1996 Sep. PMID 8922952
  4. Cloning of the cDNA coding for rat brain CMP-NeuAc:GD3 alpha2-8 sialyltransferase. Zeng G, et al. Gene, 1997 Mar 10. PMID 9073076
  5. Molecular defects that cause loss of polysialic acid in the complementation group 2A10. Windfuhr M, et al. J Biol Chem, 2000 Oct 20. PMID 10921918

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A significant decrease in ST8Sia III gene expression was found in the cerebellum of senile animals.
    Title: Differential expression of disialic acids in the cerebellum of senile mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3; sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Names
SIAT8-C
alpha-2,8-sialyltransferase 8C
alpha-2,8-sialyltransferase III
ganglioside GD3 synthase ST8SIA3
sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase
sialyltransferase 8 (alpha-2, 8-sialyltransferase) C
sialyltransferase 8C
sialyltransferase St8Sia III
sialytransferase St8Sia III
NP_033208.2
XP_030106227.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009182.3 → NP_033208.2  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

    See identical proteins and their annotated locations for NP_033208.2

    Status: VALIDATED

    Source sequence(s)
    AK015874, BB616760, BC075645
    Consensus CDS
    CCDS29301.1
    UniProtKB/Swiss-Prot
    Q64689, Q6DIB7
    UniProtKB/TrEMBL
    Q9CUJ6
    Related
    ENSMUSP00000025477.8, ENSMUST00000025477.15
    Conserved Domains (1) summary
    pfam00777
    Location:113 → 376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    64387430..64409217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250367.2 → XP_030106227.1  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q64689, Q6DIB7
    UniProtKB/TrEMBL
    Q9CUJ6
    Related
    ENSMUSP00000158392.2, ENSMUST00000237770.2
    Conserved Domains (1) summary
    pfam00777
    Location:113 → 376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64689.2 GenPept UniProtKB/Swiss-Prot:Q64689

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous