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St6galnac3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20447, updated on 5-Mar-2024

Summary

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Official Symbol
St6galnac3provided by MGI
Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:1341828
See related
Ensembl:ENSMUSG00000052544 AllianceGenome:MGI:1341828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat7c
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ceramide metabolic process; oligosaccharide metabolic process; and protein glycosylation. Predicted to be located in nucleoplasm. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lung; mammary gland; and nervous system. Orthologous to human ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 1.3), placenta adult (RPKM 1.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 H3; 3 77.82 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152903911..153430804, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153198274..153725133, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930482G09 gene Neighboring gene RIKEN cDNA 1700094M23 gene Neighboring gene STARR-seq mESC enhancer starr_09301 Neighboring gene STARR-positive B cell enhancer mm9_chr3:152853033-152853333 Neighboring gene predicted gene, 54205 Neighboring gene STARR-seq mESC enhancer starr_09302 Neighboring gene STARR-seq mESC enhancer starr_09303 Neighboring gene STARR-seq mESC enhancer starr_09304 Neighboring gene predicted gene, 33066 Neighboring gene RIKEN cDNA 1700012D16 gene Neighboring gene predicted gene, 54206 Neighboring gene predicted gene, 52634 Neighboring gene STARR-seq mESC enhancer starr_09307 Neighboring gene STARR-seq mESC enhancer starr_09311 Neighboring gene STARR-seq mESC enhancer starr_09312 Neighboring gene STARR-seq mESC enhancer starr_09315 Neighboring gene STARR-seq mESC enhancer starr_09316 Neighboring gene predicted gene, 32721 Neighboring gene predicted gene, 52633 Neighboring gene STARR-seq mESC enhancer starr_09321 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene Neighboring gene predicted gene, 22206 Neighboring gene RIKEN cDNA 5730460C07 gene Neighboring gene predicted gene, 25757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Fuseya S, et al. Sci Rep, 2023 Jun 29. PMID 37386100, Free PMC Article
  2. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. Lee YC, et al. J Biol Chem, 1999 Apr 23. PMID 10207017
  3. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Takashima S, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381338
  4. Constraint and divergence of global gene expression in the mammalian embryo. Spies N, et al. Elife, 2015 Apr 14. PMID 25871848, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
    Title: Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Names
SIAT7-C
ST6GalNAc III
ST6GalNAcIII
STY
galNAc alpha-2,6-sialyltransferase III
sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C
sialyltransferase 7C
NP_001404549.1
NP_001404550.1
NP_035502.1
XP_006501282.1
XP_006501283.1
XP_006501284.1
XP_006501285.1
XP_011238356.1
XP_030108370.1
XP_030108372.1
XP_036018881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417620.1 → NP_001404549.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC103637, AC121914, AC122052, AC133943, AC163209

  2. NM_001417621.1 → NP_001404550.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121914, AC133943, AC163209

  3. NM_011372.3 → NP_035502.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1

    See identical proteins and their annotated locations for NP_035502.1

    Status: VALIDATED

    Source sequence(s)
    AC103637, AC121914, AC133943, AC163209
    Consensus CDS
    CCDS38677.1
    UniProtKB/Swiss-Prot
    Q9JHP5, Q9WUV2
    UniProtKB/TrEMBL
    Q544M3
    Related
    ENSMUSP00000143747.2, ENSMUST00000200397.5
    Conserved Domains (1) summary
    pfam00777
    Location:77 → 297
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_184541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC103637, AC121914, AC133943, AC163209

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    152903911..153430804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252510.1 → XP_030108370.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:53 → 273
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006501220.5 → XP_006501283.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:72 → 292
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006501221.5 → XP_006501284.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:87 → 149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_006501219.5 → XP_006501282.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87 → 307
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_030252512.1 → XP_030108372.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

    Conserved Domains (1) summary
    pfam00777
    Location:7 → 209
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_036162988.1 → XP_036018881.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X8

    Conserved Domains (1) summary
    pfam00777
    Location:7 → 209
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_011240054.4 → XP_011238356.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X7

    Conserved Domains (1) summary
    pfam00777
    Location:87 → 149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_006501222.5 → XP_006501285.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:87 → 149
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_003954302.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUV2.2 GenPept UniProtKB/Swiss-Prot:Q9WUV2

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