U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20442, updated on 28-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
St3gal1provided by MGI
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by MGI
Primary source
MGI:MGI:98304
See related
Ensembl:ENSMUSG00000013846 AllianceGenome:MGI:98304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat4; Siat4a; ST3GalI; St3gal-1; 5330418N22Rik
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Acts upstream of or within protein glycosylation and protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; ear; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 22.6), liver adult (RPKM 19.4) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 D2; 15 29.3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (66974724..67048575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (67102875..67176946, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38892 Neighboring gene STARR-seq mESC enhancer starr_38895 Neighboring gene STARR-seq mESC enhancer starr_38896 Neighboring gene predicted gene, 31286 Neighboring gene predicted gene, 31342 Neighboring gene STARR-positive B cell enhancer ABC_E7376 Neighboring gene STARR-positive B cell enhancer ABC_E5486 Neighboring gene STARR-positive B cell enhancer ABC_E1907 Neighboring gene STARR-positive B cell enhancer ABC_E4135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:67041844-67042027 Neighboring gene RIKEN cDNA 1700012I11 gene Neighboring gene predicted gene, 31400 Neighboring gene STARR-seq mESC enhancer starr_38899 Neighboring gene STARR-seq mESC enhancer starr_38900 Neighboring gene STARR-seq mESC enhancer starr_38902 Neighboring gene STARR-seq mESC enhancer starr_38903 Neighboring gene predicted gene, 53906

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma. Bai Q, et al. BMC Cancer, 2015 Nov 9. PMID 26552809, Free PMC Article
  2. Mutational analysis for enzyme activity of mouse Galbeta1,3GalNAc alpha2,3-sialyltransferase (mST3Gal I). Kim KS, et al. Indian J Biochem Biophys, 2010 Jun. PMID 20653283
  3. The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development. Kao C, et al. J Immunol, 2006 Jun 15. PMID 16751387
  4. Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Grabie N, et al. Eur J Immunol, 2002 Oct. PMID 12355428
  5. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Priatel JJ, et al. Immunity, 2000 Mar. PMID 10755614

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with clear cell renal cell carcinoma
    Title: Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma.
  2. tryptophan and cysteine residues conserved in ST3Gal I are critical for its activity
    Title: Mutational analysis for enzyme activity of mouse Galbeta1,3GalNAc alpha2,3-sialyltransferase (mST3Gal I).
  3. St3gal-1 functions to protect CD8 T cells from apoptosis
    Title: The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.
  4. tissue-specific alterations in sialylation and sialic acid 9-O-acetylation in knockout mice
    Title: Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.
  5. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
    Title: Sialyltransferase specificity in selectin ligand formation.
  6. ST3Gal-I mRNA is extensively expressed during Th2, but not Th1 differentiation; suggests that lack of ST3Gal-I expression in Th1 cells allows the formation of surface core2 O-glycans and supports their interactions with endothelial selectins
    Title: Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins.
  7. STsGal-I deficiency shows no discernible effect on the pattern of CD8 noncognate binding during thymocyte development and does not impact susceptibility of thymocytes to CD8-induced apoptosis.
    Title: The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC90735

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in memory B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sialylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi medial cisterna membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi trans cisterna membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Names
CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Gal beta1,3 GalNAc alpha2,3 sialyltransferase
SIAT4-A
ST3GAL-I sialyltransferase
ST3Gal I
ST3GalA.1
ST3O
alpha 2,3-ST 1
beta-galactoside alpha-2,3-sialyltransferase 1
gal-NAc6S
gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
monosialoganglioside sialyltransferase
sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
NP_001399564.1
NP_001399565.1
NP_001399566.1
NP_033203.1
XP_006520727.1
XP_036015180.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412635.1 → NP_001399564.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q544T4

  2. NM_001412636.1 → NP_001399565.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q544T4
    Related
    ENSMUSP00000155359.2, ENSMUST00000229213.2

  3. NM_001412637.1 → NP_001399566.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q544T4
    Related
    ENSMUSP00000090307.6, ENSMUST00000092640.6

  4. NM_009177.5 → NP_033203.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_033203.1

    Status: VALIDATED

    Source sequence(s)
    AC087116, AC166984
    Consensus CDS
    CCDS27511.1
    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q3UU61, Q544T4
    Related
    ENSMUSP00000154853.2, ENSMUST00000229028.2
    Conserved Domains (1) summary
    pfam00777
    Location:80 → 335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    66974724..67048575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520664.5 → XP_006520727.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006520727.1

    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q3UU61, Q544T4
    Conserved Domains (1) summary
    pfam00777
    Location:80 → 335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_036159287.1 → XP_036015180.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P54751, Q11202
    UniProtKB/TrEMBL
    Q3UU61, Q544T4
    Conserved Domains (1) summary
    pfam00777
    Location:80 → 335
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033487.1: Suppressed sequence

    Description
    NM_001033487.1: This RefSeq was permanently suppressed because it was primarily intronic sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54751.1 GenPept UniProtKB/Swiss-Prot:P54751

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous