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Siah1b siah E3 ubiquitin protein ligase 1B [ Mus musculus (house mouse) ]

Gene ID: 20438, updated on 11-Apr-2024

Summary

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Official Symbol
Siah1bprovided by MGI
Official Full Name
siah E3 ubiquitin protein ligase 1Bprovided by MGI
Primary source
MGI:MGI:108063
See related
Ensembl:ENSMUSG00000040749 AllianceGenome:MGI:108063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sinh1b; siah-1b
Summary
This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.7), liver E14.5 (RPKM 6.2) and 28 other tissues See more
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Genomic context

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Location:
X F5; X 76.11 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162853699..162859489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164070703..164076493, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene predicted gene, 38561 Neighboring gene carbonic anhydrase 5b, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Fiucci G, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14985507, Free PMC Article
  2. Normal p53 function in primary cells deficient for Siah genes. Frew IJ, et al. Mol Cell Biol, 2002 Dec. PMID 12417719, Free PMC Article
  3. Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit. Famulski JK, et al. Science, 2010 Dec 24. PMID 21109632, Free PMC Article
  4. Cloning and characterization of the mouse PIG-A gene. Yu J, et al. Biochim Biophys Acta, 1995 Apr 6. PMID 7734452
  5. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). Della NG, et al. Development, 1993 Apr. PMID 8404535

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SIAH1B
Names
RING-type E3 ubiquitin transferase SIAH1B
drosophila seven-in-absentia gene product homolog
seven in absentia 1B
seven in absentia homolog 1b
NP_001295314.1
NP_001295315.1
NP_033199.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308385.1 → NP_001295314.1  E3 ubiquitin-protein ligase SIAH1B

    See identical proteins and their annotated locations for NP_001295314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL732294, BC052887, CF723667, CJ094899, DV648408
    Consensus CDS
    CCDS30516.1
    UniProtKB/Swiss-Prot
    Q06985, Q7TPV6
    UniProtKB/TrEMBL
    A2AHZ2
    Conserved Domains (1) summary
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family

  2. NM_001308386.1 → NP_001295315.1  E3 ubiquitin-protein ligase SIAH1B

    See identical proteins and their annotated locations for NP_001295315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL732294, BC052887, DV648408
    Consensus CDS
    CCDS30516.1
    UniProtKB/Swiss-Prot
    Q06985, Q7TPV6
    UniProtKB/TrEMBL
    A2AHZ2
    Related
    ENSMUSP00000071592.3, ENSMUST00000071667.9
    Conserved Domains (1) summary
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family

  3. NM_009173.2 → NP_033199.1  E3 ubiquitin-protein ligase SIAH1B

    See identical proteins and their annotated locations for NP_033199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL732294, BC052887, CJ063158, DV648408
    Consensus CDS
    CCDS30516.1
    UniProtKB/Swiss-Prot
    Q06985, Q7TPV6
    UniProtKB/TrEMBL
    A2AHZ2
    Related
    ENSMUSP00000043215.3, ENSMUST00000037928.9
    Conserved Domains (1) summary
    pfam03145
    Location:82 → 278
    Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162853699..162859489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06985.2 GenPept UniProtKB/Swiss-Prot:Q06985

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