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Shbg sex hormone binding globulin [ Mus musculus (house mouse) ]

Gene ID: 20415, updated on 11-Apr-2024

Summary

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Official Symbol
Shbgprovided by MGI
Official Full Name
sex hormone binding globulinprovided by MGI
Primary source
MGI:MGI:98295
See related
Ensembl:ENSMUSG00000005202 AllianceGenome:MGI:98295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ABP
Summary
Predicted to enable steroid binding activity. Predicted to be involved in primary spermatocyte growth. Predicted to be located in extracellular region. Is expressed in testis. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 8.7), liver E14 (RPKM 8.1) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69501108..69508852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69610282..69618026, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29852 Neighboring gene transformation related protein 53 Neighboring gene STARR-seq mESC enhancer starr_29854 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10681 Neighboring gene spermidine/spermine N1-acetyl transferase 2 Neighboring gene 40S ribosomal protein S15a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The androgen-binding protein gene is expressed in CD1 mouse testis. Wang YM, et al. Mol Cell Endocrinol, 1989 May. PMID 2753230
  2. Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis. Briansó-Llort L, et al. J Cell Physiol, 2022 Sep. PMID 35762039
  3. Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages. Yamazaki H, et al. Mediators Inflamm, 2018. PMID 30046278, Free PMC Article
  4. Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors. Selva DM, et al. J Biol Chem, 2005 Feb 11. PMID 15574421
  5. Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein produced by a gene distinct from Abp. Dlouhy SR, et al. Biochem Genet, 1986 Oct. PMID 3778428

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.
    Title: Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis.
  2. SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome
    Title: Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.
  3. monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression.
    Title: Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.
  4. USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter
    Title: Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors.
  5. A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens.
    Title: Dynamics of testicular germ cell apoptosis in normal mice and transgenic mice overexpressing rat androgen-binding protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in primary spermatocyte growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sex hormone-binding globulin
Names
SBP
sex steroid-binding protein
testis-specific androgen-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011367.2 → NP_035497.1  sex hormone-binding globulin precursor

    See identical proteins and their annotated locations for NP_035497.1

    Status: VALIDATED

    Source sequence(s)
    AK010959, AL731687, BC120785
    Consensus CDS
    CCDS24899.1
    UniProtKB/Swiss-Prot
    P97497, Q0VB52
    UniProtKB/TrEMBL
    A0A158SIS9
    Related
    ENSMUSP00000005334.3, ENSMUST00000005334.3
    Conserved Domains (2) summary
    pfam00054
    Location:76 → 206
    Laminin_G_1; Laminin G domain
    cl22861
    Location:225 → 369
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69501108..69508852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248838.3 → XP_011247140.1  sex hormone-binding globulin isoform X2

    Conserved Domains (1) summary
    cl22861
    Location:76 → 152
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. XM_011248837.3 → XP_011247139.1  sex hormone-binding globulin isoform X1

    See identical proteins and their annotated locations for XP_011247139.1

    UniProtKB/Swiss-Prot
    P97497, Q0VB52
    UniProtKB/TrEMBL
    A0A158SIS9
    Conserved Domains (2) summary
    pfam00054
    Location:76 → 206
    Laminin_G_1; Laminin G domain
    cl22861
    Location:225 → 369
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97497.1 GenPept UniProtKB/Swiss-Prot:P97497

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