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Sh3bp1 SH3-domain binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 20401, updated on 16-Apr-2024

Summary

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Official Symbol
Sh3bp1provided by MGI
Official Full Name
SH3-domain binding protein 1provided by MGI
Primary source
MGI:MGI:104603
See related
Ensembl:ENSMUSG00000022436 AllianceGenome:MGI:104603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3BP-1
Summary
Enables GTPase activator activity and SH3 domain binding activity. Involved in positive regulation of GTPase activity and ruffle assembly. Located in bicellular tight junction. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 61.6), spleen adult (RPKM 52.2) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.7 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78783994..78796247)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78899768..78912052)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26634 Neighboring gene STARR-positive B cell enhancer ABC_E11598 Neighboring gene STARR-positive B cell enhancer ABC_E7386 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene microRNA 6955 Neighboring gene STARR-seq mESC enhancer starr_39162 Neighboring gene STARR-positive B cell enhancer ABC_E480 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts. Cicchetti P, et al. EMBO J, 1995 Jul 3. PMID 7621827, Free PMC Article
  2. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Cicchetti P, et al. Science, 1992 Aug 7. PMID 1379745
  3. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Gout I, et al. Cell, 1993 Oct 8. PMID 8402898
  4. Identification of a ten-amino acid proline-rich SH3 binding site. Ren R, et al. Science, 1993 Feb 19. PMID 8438166
  5. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. Elbediwy A, et al. J Cell Biol, 2012 Aug 20. PMID 22891260, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316684.2 → NP_001303613.1  SH3 domain-binding protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL592169
    Consensus CDS
    CCDS84176.1
    UniProtKB/Swiss-Prot
    A2A5V4, E9QMQ2, P55194, Q99KK8
    UniProtKB/TrEMBL
    S4R2D3
    Related
    ENSMUSP00000001226.4, ENSMUST00000001226.11
    Conserved Domains (2) summary
    cd07620
    Location:16 → 275
    BAR_SH3BP1; The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1
    cl02570
    Location:272 → 473
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_001316685.2 → NP_001303614.1  SH3 domain-binding protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL592169
    Consensus CDS
    CCDS84177.1
    UniProtKB/TrEMBL
    A2A5V2, S4R2D3
    Related
    ENSMUSP00000105320.3, ENSMUST00000109698.9
    Conserved Domains (2) summary
    cl02570
    Location:272 → 473
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:16 → 275
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_009164.4 → NP_033190.2  SH3 domain-binding protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in its 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL592169
    Consensus CDS
    CCDS27626.1
    UniProtKB/TrEMBL
    A2A5V3, S4R2D3
    Related
    ENSMUSP00000052181.8, ENSMUST00000061239.14
    Conserved Domains (2) summary
    cl02570
    Location:272 → 473
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:16 → 275
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. NR_177652.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in a 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL592169

  2. NR_177653.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL592169
    Related
    ENSMUST00000151146.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78783994..78796247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001316686.1: Suppressed sequence

    Description
    NM_001316686.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  2. NR_133564.1: Suppressed sequence

    Description
    NR_133564.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55194.3 GenPept UniProtKB/Swiss-Prot:P55194

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