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Sgpl1 sphingosine phosphate lyase 1 [ Mus musculus (house mouse) ]

Gene ID: 20397, updated on 5-Mar-2024

Summary

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Official Symbol
Sgpl1provided by MGI
Official Full Name
sphingosine phosphate lyase 1provided by MGI
Primary source
MGI:MGI:1261415
See related
Ensembl:ENSMUSG00000020097 AllianceGenome:MGI:1261415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spl; S1PL; D10Xrf456
Summary
Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including animal organ development; cellular hormone metabolic process; and face morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 37.5), large intestine adult (RPKM 19.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.14 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60934421..60983463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61098642..61147684, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20611 Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 Neighboring gene STARR-positive B cell enhancer ABC_E8337 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60610293-60610594 Neighboring gene STARR-seq mESC enhancer starr_26826 Neighboring gene thymus, brain and testes associated Neighboring gene STARR-positive B cell enhancer mm9_chr10:60662268-60662569 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene predicted gene, 29861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis. Afsar SY, et al. Mol Oncol, 2022 Oct. PMID 35973936, Free PMC Article
  2. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Spohner AK, et al. Int J Mol Sci, 2021 Sep 30. PMID 34638955, Free PMC Article
  3. Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome. Zhao P, et al. JCI Insight, 2021 Apr 22. PMID 33755599, Free PMC Article
  4. Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy. Kageyama Y, et al. Biosci Rep, 2020 Jul 31. PMID 32614038, Free PMC Article
  5. Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P(2) receptor axis. Cencetti F, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Sep. PMID 32565314

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
    Title: Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis.
  2. Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
    Title: Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
  3. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
    Title: SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
  4. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
    Title: Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
  5. Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development.
    Title: Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development.
  6. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
    Title: S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
  7. Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
    Title: Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation.
  8. Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
    Title: Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.
  9. Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P2 receptor axis.
    Title: Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P(2) receptor axis.
  10. S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.
    Title: S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables sphinganine-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphinganine-1-phosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within estrogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within luteinization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sphingosine-1-phosphate lyase 1
Names
SP-lyase 1
SPL 1
sphingosine-1-phosphate aldolase
NP_001303602.1
NP_001303603.1
NP_033189.2
XP_017169349.1
XP_036011604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316673.1 → NP_001303602.1  sphingosine-1-phosphate lyase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK049342, BB854743
    Consensus CDS
    CCDS35914.1
    UniProtKB/Swiss-Prot
    O54955, Q8C942, Q8R0X7
    UniProtKB/TrEMBL
    Q3UDJ2, Q4FK38
    Related
    ENSMUSP00000090155.6, ENSMUST00000092498.12
    Conserved Domains (1) summary
    cd06450
    Location:146 → 507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  2. NM_001316674.1 → NP_001303603.1  sphingosine-1-phosphate lyase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK036747, BB854743, CD554088
    Consensus CDS
    CCDS35914.1
    UniProtKB/Swiss-Prot
    O54955, Q8C942, Q8R0X7
    UniProtKB/TrEMBL
    Q3UDJ2, Q4FK38
    Conserved Domains (1) summary
    cd06450
    Location:146 → 507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  3. NM_009163.4 → NP_033189.2  sphingosine-1-phosphate lyase 1

    See identical proteins and their annotated locations for NP_033189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC123530, AI428538, AK036747, BB620054, BB854743
    Consensus CDS
    CCDS35914.1
    UniProtKB/Swiss-Prot
    O54955, Q8C942, Q8R0X7
    UniProtKB/TrEMBL
    Q3UDJ2, Q4FK38
    Related
    ENSMUSP00000112975.2, ENSMUST00000122259.8
    Conserved Domains (1) summary
    cd06450
    Location:146 → 507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    60934421..60983463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155711.1 → XP_036011604.1  sphingosine-1-phosphate lyase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54955, Q8C942, Q8R0X7
    UniProtKB/TrEMBL
    Q3UDJ2, Q4FK38
    Conserved Domains (1) summary
    cd06450
    Location:146 → 507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

  2. XM_017313860.3 → XP_017169349.1  sphingosine-1-phosphate lyase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54955, Q8C942, Q8R0X7
    UniProtKB/TrEMBL
    Q3UDJ2, Q4FK38
    Conserved Domains (1) summary
    cd06450
    Location:146 → 507
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0X7.1 GenPept UniProtKB/Swiss-Prot:Q8R0X7

Gene LinkOut

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