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Sftpb surfactant associated protein B [ Mus musculus (house mouse) ]

Gene ID: 20388, updated on 21-Apr-2024

Summary

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Official Symbol
Sftpbprovided by MGI
Official Full Name
surfactant associated protein Bprovided by MGI
Primary source
MGI:MGI:109516
See related
Ensembl:ENSMUSG00000056370 AllianceGenome:MGI:109516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SF-B; SP-B; Sftp3; Sftp-3
Summary
Predicted to be involved in sphingolipid metabolic process. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in respiratory system. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward lung adult (RPKM 2635.4) See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72281594..72291354)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72304610..72314373)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene atonal bHLH transcription factor 8 Neighboring gene predicted gene, 52906 Neighboring gene predicted gene, 30782 Neighboring gene STARR-seq mESC enhancer starr_16282 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:72295216-72295399 Neighboring gene RIKEN cDNA 0610030E20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant Protein B Alleviates Inflammatory Response in Acute Respiratory Distress Syndrome by Regulating Macrophage Polarization.
    Title: Umbilical Cord-derived Mesenchymal Stem Cells with Surfactant Protein B Alleviates Inflammatory Response in Acute Respiratory Distress Syndrome by Regulating Macrophage Polarization.
  2. Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
    Title: Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
  3. This study investigated the relationship between abnormal alveolar micromechanics, alveolar epithelial injury, intra-alveolar fluid properties and remodeling in the conditional surfactant protein B (SP-B) knockout mouse model.
    Title: Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury.
  4. EMC3 was essential for the processing and routing of surfactant proteins, SP-B and SP-C, and the biogenesis of the phospholipid transport protein ABCA3.
    Title: EMC3 coordinates surfactant protein and lipid homeostasis required for respiration.
  5. In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A and SPC but not SPB and SPD expression.
    Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
  6. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production.
    Title: Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production.
  7. These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function.
    Title: Identification of vitamin D sensitive pathways during lung development.
  8. Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays.
    Title: Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.
  9. macrophages participate in the repression of SFTPB expression by LPS, and that macrophage-released cytokines (including TNF) regulate the transcription factor CEBPB
    Title: LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells.
  10. Tuberous sclerosis complex 1 contributes to the regulation of synthesis of surfactant proteins A and B.
    Title: Deficiency in pulmonary surfactant proteins in mice with fatty acid binding protein 4-Cre-mediated knockout of the tuberous sclerosis complex 1 gene.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in alveolar lamellar body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pulmonary surfactant-associated protein B
Names
pulmonary surfactant-associated proteolipid SPL(Phe)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282071.3 → NP_001269000.1  pulmonary surfactant-associated protein B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116115, FO681326
    Consensus CDS
    CCDS71775.1
    UniProtKB/TrEMBL
    S4R2L6
    Related
    ENSMUSP00000138695.2, ENSMUST00000183018.8
    Conserved Domains (4) summary
    smart00741
    Location:66 → 142
    SapB; Saposin (B) Domains
    pfam03489
    Location:111 → 142
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:68 → 102
    SapB_1; Saposin-like type B, region 1
    cl02494
    Location:27 → 60
    SapA; Saposin A-type domain

  2. NM_147779.3 → NP_680088.1  pulmonary surfactant-associated protein B isoform 1 precursor

    See identical proteins and their annotated locations for NP_680088.1

    Status: VALIDATED

    Source sequence(s)
    AC116115, FO681326
    UniProtKB/Swiss-Prot
    P50405
    Related
    ENSMUSP00000138204.4, ENSMUST00000182014.10
    Conserved Domains (4) summary
    smart00741
    Location:66 → 142
    SapB; Saposin (B) Domains
    pfam03489
    Location:111 → 142
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:68 → 102
    SapB_1; Saposin-like type B, region 1
    cl02494
    Location:27 → 60
    SapA; Saposin A-type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72281594..72291354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50405.1 GenPept UniProtKB/Swiss-Prot:P50405

Gene LinkOut

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