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Sema4c sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C [ Mus musculus (house mouse) ]

Gene ID: 20353, updated on 21-Apr-2024

Summary

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Official Symbol
Sema4cprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Cprovided by MGI
Primary source
MGI:MGI:109252
See related
Ensembl:ENSMUSG00000026121 AllianceGenome:MGI:109252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Semaf; Semai; sema I; Semacl1; M-Sema F
Summary
This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.0), CNS E14 (RPKM 13.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 15.32 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36587720..36599780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36548639..36560699, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:36568490-36568791 Neighboring gene cyclin M3 Neighboring gene ankyrin repeat domain 23 Neighboring gene STARR-positive B cell enhancer ABC_E320 Neighboring gene ankyrin repeat domain 39 Neighboring gene family with sequence similarity 178, member B Neighboring gene STARR-seq mESC enhancer starr_00646 Neighboring gene cytochrome c oxidase subunit 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement. Chen D, et al. Mol Hum Reprod, 2023 Apr 29. PMID 36892447
  2. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology. Simonetti M, et al. Mol Psychiatry, 2021 Apr. PMID 31444474, Free PMC Article
  3. Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain. Paldy E, et al. Nat Commun, 2017 Aug 2. PMID 28765520, Free PMC Article
  4. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. Xue D, et al. J Immunol, 2017 Jan 1. PMID 27881703
  5. Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia. Wu H, et al. J Mol Neurosci, 2009 Sep. PMID 19189244

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement.
    Title: Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement.
  2. The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
    Title: The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
  3. Follicular T helper cells use Semaphorin 4C as a guidance receptor to sense germinal center-expressed Plexin B2.
    Title: Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center.
  4. we demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138(+) B cells.
    Title: Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells.
  5. Sema4C-Plexin B2 signalling regulates ureteric branching
    Title: Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.
  6. We have identified here Sema4C and Sema4G as candidate ligands for Plexin-B2
    Title: Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
  7. Plexin-B2 and Sema4C are potential regulators of the vascular and endocrine system.
    Title: A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.
  8. Results suggest a putative role of Sema4C during neurogenesis both in vivo and in vitro.
    Title: Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia.
  9. Sema4C promotes terminal myogenic differentiation in a p38 MAPK-dependent manner.
    Title: Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway.
  10. Sema4C-mediated interaction among myoblasts plays an important role in terminal myogenic differentiation
    Title: Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration in hindbrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
semaphorin-4C
Names
semaphorin I
semaphorin-C-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126047.3 → NP_001119519.1  semaphorin-4C precursor

    See identical proteins and their annotated locations for NP_001119519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC084391, AK148298, BY166322
    Consensus CDS
    CCDS48240.1
    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Related
    ENSMUSP00000110643.2, ENSMUST00000114991.8
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  2. NM_001304329.1 → NP_001291258.1  semaphorin-4C precursor

    See identical proteins and their annotated locations for NP_001291258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC084391, AK148298
    Consensus CDS
    CCDS48240.1
    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Related
    ENSMUSP00000141527.2, ENSMUST00000195620.6
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  3. NM_001304330.1 → NP_001291259.1  semaphorin-4C precursor

    See identical proteins and their annotated locations for NP_001291259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC084391, AK148298
    Consensus CDS
    CCDS48240.1
    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Related
    ENSMUSP00000142284.2, ENSMUST00000191642.6
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36587720..36599780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162916.1 → XP_036018809.1  semaphorin-4C isoform X2

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  2. XM_006495805.3 → XP_006495868.1  semaphorin-4C isoform X2

    See identical proteins and their annotated locations for XP_006495868.1

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Related
    ENSMUSP00000141263.2, ENSMUST00000191677.6
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  3. XM_017319410.2 → XP_017174899.1  semaphorin-4C isoform X3

    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    smart00423
    Location:358 → 387
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:430 → 438
    Ig; Ig strand B [structural motif]
    cl11960
    Location:423 → 507
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 357
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  4. XM_036162919.1 → XP_036018812.1  semaphorin-4C isoform X3

    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    smart00423
    Location:358 → 387
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:430 → 438
    Ig; Ig strand B [structural motif]
    cl11960
    Location:423 → 507
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 357
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  5. XM_006495808.3 → XP_006495871.1  semaphorin-4C isoform X2

    See identical proteins and their annotated locations for XP_006495871.1

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  6. XM_030252338.1 → XP_030108198.1  semaphorin-4C isoform X2

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  7. XM_006495804.3 → XP_006495867.1  semaphorin-4C isoform X1

    Conserved Domains (3) summary
    cd11258
    Location:151 → 607
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:608 → 637
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:673 → 757
    Ig; Immunoglobulin domain

  8. XM_006495807.1 → XP_006495870.1  semaphorin-4C isoform X2

    See identical proteins and their annotated locations for XP_006495870.1

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  9. XM_006495810.5 → XP_006495873.1  semaphorin-4C isoform X2

    See identical proteins and their annotated locations for XP_006495873.1

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  10. XM_006495809.5 → XP_006495872.1  semaphorin-4C isoform X2

    See identical proteins and their annotated locations for XP_006495872.1

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain

  11. XM_036162917.1 → XP_036018810.1  semaphorin-4C isoform X2

    UniProtKB/Swiss-Prot
    Q64151
    UniProtKB/TrEMBL
    Q69ZB9
    Conserved Domains (4) summary
    cd11258
    Location:42 → 498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499 → 528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00096
    Location:571 → 579
    Ig; Ig strand B [structural motif]
    cl11960
    Location:564 → 648
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64151.1 GenPept UniProtKB/Swiss-Prot:Q64151

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