Selenbp1 selenium binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Selenbp1provided by MGI
Official Full Name: selenium binding protein 1provided by MGI
Primary source: MGI:MGI:96825
See related: Ensembl:ENSMUSG00000068874 AllianceGenome:MGI:96825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTO; Lp56; Lpsb; SBP56
Summary: Predicted to enable selenium binding activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in fibrillar center. Is expressed in several structures, including gut; liver; lung; male reproductive gland or organ; and olfactory epithelium. Orthologous to human SELENBP1 (selenium binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 532.7), lung adult (RPKM 367.8) and 16 other tissues See more
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94840394..94852069)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (94933083..94944758)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of Selenbp1 Alters Lipid Metabolism via the Pparalpha Pathway in Mouse Kidney.
Title: Ablation of Selenbp1 Alters Lipid Metabolism via the Pparα Pathway in Mouse Kidney.
Data demonstrate that Selenbp1 is a direct target of Nkx2-1, which inhibits lung adenocarcinoma growth in vivo. Selenbp1 is an important suppressor of lung tumor growth that functions in a positive feedback loop with Nkx2-1, and whose loss is associated with worse patient outcome.
Title: Tumor Suppressor Activity of Selenbp1, a Direct Nkx2-1 Target, in Lung Adenocarcinoma.
oxidative stress-induced DNA methylation of miR-122 aggravates colitis targeting SELENBP1 partially by p65NF-kappaB signaling and may promote the progression of Crohn's disease.
Title: DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-κB Signaling.
SELENBP1 is a marker of cell differentiation/maturation rather than being linked to lipogenesis/lipid accumulation.
Title: Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes.
These results have revealed a novel mechanism that SELENBP1-mediated cancer inhibition is through altering lipid/glucose metabolic signaling pathways.
Title: Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
Selenbp1 suppresses the expression of tumor-promoting genes
Title: Selenium-binding protein 1: its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
SBP1 has tumor suppressor functions that are inhibited in colorectal cancer through epigenetic silencing
Title: Transcriptional regulation and biological functions of selenium-binding protein 1 in colorectal cancer in vitro and in nude mouse xenografts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144390

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144391

Selenbp1 (e-PCR), detects polymorphism
- UniSTS:144392

32.MMHAP10FC5.seq (e-PCR)
- UniSTS:123973

M32032 (e-PCR)
- UniSTS:178874

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methanethiol oxidase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables selenium binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methanethiol oxidase

Names: 56 kDa selenium-binding protein; SP56

NP_033176.2

EC 1.8.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.