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Exoc4 exocyst complex component 4 [ Mus musculus (house mouse) ]

Gene ID: 20336, updated on 11-Apr-2024

Summary

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Official Symbol
Exoc4provided by MGI
Official Full Name
exocyst complex component 4provided by MGI
Primary source
MGI:MGI:1096376
See related
Ensembl:ENSMUSG00000029763 AllianceGenome:MGI:1096376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec8; Sec8l1
Summary
Enables PDZ domain binding activity. Involved in cilium assembly and protein localization to ciliary membrane. Acts upstream of or within paraxial mesoderm formation. Located in growth cone membrane; microvillus; and myelin sheath abaxonal region. Is expressed in several structures, including central nervous system; extraembryonic component; ganglia; and retina. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 5.5), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 14.59 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (33226025..33950914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (33249090..33973979)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15518 Neighboring gene predicted gene, 22321 Neighboring gene STARR-seq mESC enhancer starr_15519 Neighboring gene STARR-seq mESC enhancer starr_15522 Neighboring gene STARR-seq mESC enhancer starr_15523 Neighboring gene zinc finger protein 212 pseudogene Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 38785 Neighboring gene STARR-seq mESC enhancer starr_15525 Neighboring gene STARR-seq mESC enhancer starr_15527 Neighboring gene STARR-seq mESC enhancer starr_15528 Neighboring gene STARR-seq mESC enhancer starr_15529 Neighboring gene STARR-positive B cell enhancer ABC_E10372 Neighboring gene predicted gene 13853 Neighboring gene predicted gene, 38786 Neighboring gene leucine-rich repeats and guanylate kinase domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. Lyons PD, et al. Biosci Rep, 2009 Aug. PMID 19006485, Free PMC Article
  2. CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion. Liu J, et al. Stem Cells, 2016 Nov. PMID 27334848
  3. Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis. Tsuboi T, et al. J Biol Chem, 2005 Jul 8. PMID 15878854
  4. LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8. Fais M, et al. Cells, 2021 Jan 20. PMID 33498474, Free PMC Article
  5. The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium. Boukhalfa A, et al. Cell Rep, 2021 Apr 27. PMID 33910006

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
    Title: LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
  2. CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion.
    Title: CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
  3. Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
    Title: Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
  4. Interaction of Discs large 1 (Dlg1) with the Sec8 exocyst component promotes membrane addition, whereas with myotubularin-related protein 2 (Mtmr2), negatively regulates membrane formation.
    Title: Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
  5. SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Interactions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
    Title: NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.
  6. the exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane
    Title: Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis.
  7. Sec8 controls the directional movement of AMPA receptors towards synapses through PDZ-dependent interactions.
    Title: Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to transport vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with endosome ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
is_active_in growth cone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exocyst complex component 4
Names
SEC8-like 1
exocyst complex component Sec8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347089.2 → NP_001334018.1  exocyst complex component 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC132453, AC152961
    Consensus CDS
    CCDS85028.1
    UniProtKB/TrEMBL
    Q8C391, Q9CXE1
    Related
    ENSMUSP00000087859.5, ENSMUST00000090381.11

  2. NM_009148.4 → NP_033174.2  exocyst complex component 4 isoform 1

    See identical proteins and their annotated locations for NP_033174.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132453, AC141927, AC152961, AC154020, AC155915
    Consensus CDS
    CCDS19987.1
    UniProtKB/Swiss-Prot
    O35382
    UniProtKB/TrEMBL
    Q69ZD1
    Related
    ENSMUSP00000051965.9, ENSMUST00000052266.15
    Conserved Domains (1) summary
    pfam04048
    Location:57 → 143
    Sec8_exocyst; Sec8 exocyst complex component specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    33226025..33950914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241262.1 → XP_011239564.1  exocyst complex component 4 isoform X1

    UniProtKB/TrEMBL
    Q8CA11
    Conserved Domains (1) summary
    pfam04048
    Location:57 → 143
    Sec8_exocyst; Sec8 exocyst complex component specific domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35382.2 GenPept UniProtKB/Swiss-Prot:O35382

Gene LinkOut

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