Sec22b SEC22 homolog B, vesicle trafficking protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec22bprovided by MGI
Official Full Name: SEC22 homolog B, vesicle trafficking proteinprovided by MGI
Primary source: MGI:MGI:1338759
See related: Ensembl:ENSMUSG00000027879 AllianceGenome:MGI:1338759
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERS-24; Sec22l1; 4930564D15Rik
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within vesicle-mediated transport. Located in Golgi membrane and endoplasmic reticulum membrane. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 47.1), limb E14.5 (RPKM 29.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 42.35 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (97808543..97829634)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (97901227..97922318)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro.
Title: Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro.
Sec22b is a critical and nonredundant regulator of plasma cell maintenance.
Title: Sec22b is a critical and nonredundant regulator of plasma cell maintenance.
Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-kappaB and the Secretion of Inflammatory Mediators.
Title: Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-κB and the Secretion of Inflammatory Mediators.
SNARE protein SEC22B regulates early embryonic development.
Title: SNARE protein SEC22B regulates early embryonic development.
this mini review evaluates the role of Sec22b using gene-targeted mice in MHC Class I cross-presentation.
Title: MHC Class I Cross-Presentation: Stage Lights on Sec22b.
study finds that presentation of the membrane-bound GRA6 Toxoplasma gondii antigen is independent from the SNARE Sec22b, a key molecule for transfer of host endoplasmic reticulum components onto the parasitophorous vacuole
Title: MHC I presentation of Toxoplasma gondii immunodominant antigen does not require Sec22b and is regulated by antigen orientation at the vacuole membrane.
required in cross-presentation in dendritic cells to initiate CD8+ T cell responses to dead cells and to induce effective antitumor immune responses
Title: Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
Suggest that close apposition of the ER and plasma membrane mediated by Sec22b and plasma membrane syntaxins generates a non-fusogenic SNARE bridge contributing to plasma membrane expansion, probably through non-vesicular lipid transfer.
Title: The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion.
Findings provide insight into an intracellular traffic pathway required for crosspresentation and show that Sec22b-dependent recruitment of endoplasmic reticulum proteins to phagosomes critically influences phagosomal functions in dendritic cells.
Title: Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
The R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis. Sec22b is a negative regulator of phagocytosis in macrophages by regulating free syntaxin 18 and/or D12.
Title: Sec22b is a negative regulator of phagocytosis in macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142986 (e-PCR)
- UniSTS:232233

AI480645 (e-PCR)
- UniSTS:159153

RH127058 (e-PCR)
- UniSTS:207541

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ER to Golgi transport vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicle-trafficking protein SEC22b

Names: ER-Golgi SNARE of 24 kDa; ERS24; SEC22 vesicle trafficking protein homolog B; SEC22 vesicle trafficking protein-like 1; mSec22b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.