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Frrs1 ferric-chelate reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 20321, updated on 21-Apr-2024

Summary

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Official Symbol
Frrs1provided by MGI
Official Full Name
ferric-chelate reductase 1provided by MGI
Primary source
MGI:MGI:108076
See related
Ensembl:ENSMUSG00000033386 AllianceGenome:MGI:108076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDR-2; Sdfr2
Summary
Enables oxidoreductase activity, acting on metal ions. Involved in cellular iron ion homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in liver left lobe; liver lobe; and liver right lobe. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 6.5), liver E14 (RPKM 6.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 50.49 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116653212..116701363)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116859567..116907714)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4582 Neighboring gene predicted gene, 40128 Neighboring gene predicted gene, 29736 Neighboring gene STARR-seq mESC enhancer starr_08799 Neighboring gene palmdelphin Neighboring gene STARR-seq mESC enhancer starr_08800 Neighboring gene predicted gene, 32148 Neighboring gene predicted gene, 52613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body. Zhu Y, et al. Insect Biochem Mol Biol, 2003 May. PMID 12706633
  2. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas JD, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499595
  3. Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Shirozu M, et al. Genomics, 1996 Nov 1. PMID 8938438
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on metal ions IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on metal ions IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ferric-chelate reductase 1
Names
stromal cell derived factor receptor 2
stromal cell-derived receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113478.2 → NP_001106950.1  ferric-chelate reductase 1 precursor

    See identical proteins and their annotated locations for NP_001106950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC170869, AC174779
    Consensus CDS
    CCDS17792.1
    UniProtKB/Swiss-Prot
    P97301, Q3TJV0, Q3UMF5, Q8K385
    UniProtKB/TrEMBL
    A0A0G2JFP4
    Related
    ENSMUSP00000039487.7, ENSMUST00000040260.11
    Conserved Domains (3) summary
    cd08760
    Location:320 → 533
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 354
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain

  2. NM_009146.4 → NP_033172.2  ferric-chelate reductase 1 precursor

    See identical proteins and their annotated locations for NP_033172.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC170869
    Consensus CDS
    CCDS17792.1
    UniProtKB/Swiss-Prot
    P97301, Q3TJV0, Q3UMF5, Q8K385
    UniProtKB/TrEMBL
    A0A0G2JFP4
    Related
    ENSMUSP00000143255.2, ENSMUST00000195905.5
    Conserved Domains (3) summary
    cd08760
    Location:320 → 533
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 354
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116653212..116701363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319511.2 → XP_017175000.1  ferric-chelate reductase 1 isoform X1

    UniProtKB/Swiss-Prot
    P97301, Q3TJV0, Q3UMF5, Q8K385
    Conserved Domains (3) summary
    cd08760
    Location:287 → 500
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 321
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain

  2. XM_006501185.5 → XP_006501248.1  ferric-chelate reductase 1 isoform X2

    Conserved Domains (2) summary
    cd08760
    Location:38 → 251
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cl14783
    Location:1 → 72
    DOMON_like; Domon-like ligand-binding domains

RNA

  1. XR_001783669.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K385.1 GenPept UniProtKB/Swiss-Prot:Q8K385

Gene LinkOut

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