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TMEM268 transmembrane protein 268 [ Homo sapiens (human) ]

Gene ID: 203197, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM268provided by HGNC
Official Full Name
transmembrane protein 268provided by HGNC
Primary source
HGNC:HGNC:24513
See related
Ensembl:ENSG00000157693 AllianceGenome:HGNC:24513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf91
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.4), spleen (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114603904..114646422)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126796322..126838835)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117373571..117408702)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376229 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:117345492-117345996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117348508-117349327 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117349328-117350146 Neighboring gene ATPase H+ transporting V1 subunit G1 Neighboring gene MPRA-validated peak7324 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28873 Neighboring gene NANOG hESC enhancer GRCh37_chr9:117415620-117416126 Neighboring gene uncharacterized LOC107987121 Neighboring gene testis expressed 53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway. Hong D, et al. Cell Death Differ, 2019 Aug. PMID 30361615, Free PMC Article
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
  3. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
  4. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474
  5. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway.
    Title: Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38045, MGC129868, MGC129869, DKFZp547P234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 268
Names
transmembrane protein C9orf91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330760.2 → NP_001317689.1  transmembrane protein 268 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160275, AL557166, AL834412, AW963631, BC010029, CB121579, DB199443, HY066490
    Consensus CDS
    CCDS83405.1
    UniProtKB/TrEMBL
    A8K018
    Related
    ENSP00000363161.4, ENST00000374049.4

  2. NM_153045.4 → NP_694590.2  transmembrane protein 268 isoform 1

    See identical proteins and their annotated locations for NP_694590.2

    Status: VALIDATED

    Source sequence(s)
    AK095364, AL160275, BC010029, BC107133, DB199443
    Consensus CDS
    CCDS6808.1
    UniProtKB/Swiss-Prot
    A0PJA3, Q3KNS4, Q5VZI2, Q5VZI3, Q6P5Z7, Q8N1P3, Q8ND43
    UniProtKB/TrEMBL
    A8K018
    Related
    ENSP00000288502.4, ENST00000288502.9
    Conserved Domains (1) summary
    pfam14800
    Location:38 → 328
    DUF4481; Domain of unknown function (DUF4481)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    114603904..114646422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518351.3 → XP_011516653.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_011516653.1

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:104 → 395
    DUF4481; Domain of unknown function (DUF4481)

  2. XM_047422925.1 → XP_047278881.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    A0PJA3, Q3KNS4, Q5VZI2, Q5VZI3, Q6P5Z7, Q8N1P3, Q8ND43

  3. XM_011518350.2 → XP_011516652.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_011516652.1

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:104 → 395
    DUF4481; Domain of unknown function (DUF4481)

  4. XM_011518353.2 → XP_011516655.1  transmembrane protein 268 isoform X3

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:104 → 358
    DUF4481; Domain of unknown function (DUF4481)

  5. XM_011518352.2 → XP_011516654.1  transmembrane protein 268 isoform X2

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:104 → 394
    DUF4481; Domain of unknown function (DUF4481)

  6. XM_047422923.1 → XP_047278879.1  transmembrane protein 268 isoform X4

  7. XM_047422927.1 → XP_047278883.1  transmembrane protein 268 isoform X9

  8. XM_047422928.1 → XP_047278884.1  transmembrane protein 268 isoform X10

  9. XM_024447441.1 → XP_024303209.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    A0PJA3, Q3KNS4, Q5VZI2, Q5VZI3, Q6P5Z7, Q8N1P3, Q8ND43
    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:38 → 328
    DUF4481; Domain of unknown function (DUF4481)

  10. XM_047422924.1 → XP_047278880.1  transmembrane protein 268 isoform X5

  11. XM_011518354.2 → XP_011516656.1  transmembrane protein 268 isoform X7

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:17 → 308
    DUF4481; Domain of unknown function (DUF4481)

  12. XM_047422929.1 → XP_047278885.1  transmembrane protein 268 isoform X11

  13. XM_011518355.2 → XP_011516657.1  transmembrane protein 268 isoform X8

    See identical proteins and their annotated locations for XP_011516657.1

    UniProtKB/TrEMBL
    A8K018
    Conserved Domains (1) summary
    pfam14800
    Location:17 → 307
    DUF4481; Domain of unknown function (DUF4481)

  14. XM_017014430.2 → XP_016869919.1  transmembrane protein 268 isoform X12

RNA

  1. XR_001746225.2 RNA Sequence

  2. XR_007061260.1 RNA Sequence

  3. XR_001746226.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    126796322..126838835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362258.1 → XP_054218233.1  transmembrane protein 268 isoform X1

  2. XM_054362263.1 → XP_054218238.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    A0PJA3, Q3KNS4, Q5VZI2, Q5VZI3, Q6P5Z7, Q8N1P3, Q8ND43

  3. XM_054362257.1 → XP_054218232.1  transmembrane protein 268 isoform X1

  4. XM_054362260.1 → XP_054218235.1  transmembrane protein 268 isoform X3

  5. XM_054362259.1 → XP_054218234.1  transmembrane protein 268 isoform X2

  6. XM_054362261.1 → XP_054218236.1  transmembrane protein 268 isoform X4

  7. XM_054362267.1 → XP_054218242.1  transmembrane protein 268 isoform X9

  8. XM_054362268.1 → XP_054218243.1  transmembrane protein 268 isoform X10

  9. XM_054362264.1 → XP_054218239.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    A0PJA3, Q3KNS4, Q5VZI2, Q5VZI3, Q6P5Z7, Q8N1P3, Q8ND43

  10. XM_054362262.1 → XP_054218237.1  transmembrane protein 268 isoform X5

  11. XM_054362265.1 → XP_054218240.1  transmembrane protein 268 isoform X7

  12. XM_054362269.1 → XP_054218244.1  transmembrane protein 268 isoform X11

  13. XM_054362266.1 → XP_054218241.1  transmembrane protein 268 isoform X8

  14. XM_054362270.1 → XP_054218245.1  transmembrane protein 268 isoform X12

RNA

  1. XR_008487959.1 RNA Sequence

  2. XR_008487960.1 RNA Sequence

  3. XR_008487961.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VZI3.1 GenPept UniProtKB/Swiss-Prot:Q5VZI3

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