Ccl6 C-C motif chemokine ligand 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl6provided by MGI
Official Full Name: C-C motif chemokine ligand 6provided by MGI
Primary source: MGI:MGI:98263
See related: Ensembl:ENSMUSG00000018927 AllianceGenome:MGI:98263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: c10; MRP-1; Scya6
Summary: Predicted to enable CCR1 chemokine receptor binding activity; chemoattractant activity; and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to several human genes including CCL23 (C-C motif chemokine ligand 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 48.7), colon adult (RPKM 38.0) and 11 other tissues See more
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Genomic context

Location:: 11 C; 11 50.85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83478712..83483913, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83587886..83593087, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection.
Title: Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection.
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Title: CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation.
Title: Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation.
this study reveals an unexpected function of eosinophil-derived CCL-6 in hematopoietic stem cell homeostasis.
Title: Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis.
Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
Title: Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines
Title: A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP
Title: ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.
CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation.
Title: Stem cell factor-mediated activation pathways promote murine eosinophil CCL6 production and survival.
the injury-induced expression of C10 at the mRNA and protein level
Title: The healing skin wound: a novel site of action of the chemokine C10.
c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung
Title: Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Markers

D11Mit120 (e-PCR), detects polymorphism
- UniSTS:126310

NoName (e-PCR)
- UniSTS:236673

D11Pas18 (e-PCR), detects polymorphism
- UniSTS:209580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 6

Names: CC chemokine C10; chemokine (C-C motif) ligand 6; small-inducible cytokine A6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009139.3 → NP_033165.1 C-C motif chemokine 6 precursor

See identical proteins and their annotated locations for NP_033165.1

Status: VALIDATED

Source sequence(s)

AK002697, AV014853, BY172106, M58004

Consensus CDS

CCDS25171.1

UniProtKB/Swiss-Prot

P27784, Q3U3W3, Q5QNW1, Q99M24, Q9D830

Related

ENSMUSP00000019071.4, ENSMUST00000019071.4

Conserved Domains (1) summary

cd00272
Location:50 → 105

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...