Stmn2 stathmin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stmn2provided by MGI
Official Full Name: stathmin-like 2provided by MGI
Primary source: MGI:MGI:98241
See related: Ensembl:ENSMUSG00000027500 AllianceGenome:MGI:98241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCG10; Stmb2; Scgn10
Summary: Predicted to enable calcium-dependent protein binding activity and tubulin binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; regulation of microtubule polymerization or depolymerization; and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including alimentary system; autopod; genitourinary system; nervous system; and nose. Orthologous to human STMN2 (stathmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 490.1), whole brain E14.5 (RPKM 244.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 2.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (8574587..8626664)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (8509527..8561604)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.
Title: Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.
SCG10 is required for peripheral axon maintenance and regeneration in mice.
Title: SCG10 is required for peripheral axon maintenance and regeneration in mice.
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy.
Title: Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy.
Loss of mouse Stmn2 function causes motor neuropathy.
Title: Loss of mouse Stmn2 function causes motor neuropathy.
Misrouting of glucagon and stathmin-2 towards lysosomal system of alpha-cells in glucagon hypersecretion of diabetes.
Title: Misrouting of glucagon and stathmin-2 towards lysosomal system of α-cells in glucagon hypersecretion of diabetes.
Stathmin-2 Mediates Glucagon Secretion From Pancreatic alpha-Cells.
Title: Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells.
Stmn2 reduction in the mouse midbrain causes dopaminergic neuron degeneration, phosphorylated alpha-synuclein elevation, and locomotor deficits. STMN2 functions in synaptic trafficking in mouse dopaminergic neurons.
Title: The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.
autophagy induction stabilized microtubules by degrading SCG10, a microtubule disassembly protein in neurons. In mice with spinal cord injury, local administration of a specific autophagy-inducing peptide, Tat-beclin1, to lesion sites markedly attenuated axonal retraction of spinal dorsal column axons and cortical spinal tract and promoted regeneration of descending axons following long-term observation
Title: Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury.
SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface.
Title: SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface.
This study demonstrated that axonal injury induces a dynamic regulation of SCG10 protein levels with selective accumulation in proximal axon segments.
Title: Dynamic regulation of SCG10 in regenerating axons after injury.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI159727 (e-PCR)
- UniSTS:178803

D8S1388E (e-PCR)
- UniSTS:151190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stathmin-2

Names: superior cervical ganglion-10 protein; superiorcervical ganglia, neural specific 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.