U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Scg3 secretogranin III [ Mus musculus (house mouse) ]

Gene ID: 20255, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Scg3provided by MGI
Official Full Name
secretogranin IIIprovided by MGI
Primary source
MGI:MGI:103032
See related
Ensembl:ENSMUSG00000032181 AllianceGenome:MGI:103032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chgd; SgIII; 1B1075
Summary
Acts upstream of or within protein localization to secretory granule. Located in secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human SCG3 (secretogranin III). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 14.7), cortex adult (RPKM 13.8) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 D; 9 42.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75550648..75591733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75643366..75685959, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene tropomodulin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_24672 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_24674 Neighboring gene STARR-seq mESC enhancer starr_24675 Neighboring gene predicted gene, 39373

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization. Ji L, et al. FEBS J, 2022 Jun. PMID 35038348, Free PMC Article
  2. Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy. Dai C, et al. Cell Mol Life Sci, 2022 Jan 10. PMID 35006382, Free PMC Article
  3. Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization. Ji L, et al. FASEB J, 2022 Jan. PMID 34918375, Free PMC Article
  4. Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease. Wen G, et al. Aging (Albany NY), 2021 Aug 21. PMID 34420933, Free PMC Article
  5. Expression Pattern of the LacZ Reporter in Secretogranin III Gene-trapped Mice. Gomi H, et al. J Histochem Cytochem, 2021 Apr. PMID 33622062, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization.
    Title: Comparative ligandomics implicates secretogranin III as a disease-restricted angiogenic factor in laser-induced choroidal neovascularization.
  2. Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease.
    Title: Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson's disease.
  3. Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy.
    Title: Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy.
  4. Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization.
    Title: Selectively targeting disease-restricted secretogranin III to alleviate choroidal neovascularization.
  5. Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
    Title: Concurrent Physiological and Pathological Angiogenesis in Retinopathy of Prematurity and Emerging Therapies.
  6. This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy.[ review]
    Title: Secretogranin III: a diabetic retinopathy-selective angiogenic factor.
  7. we show by RNA silencing that CPE and SgIII play a synergistic role in the trafficking of POMC to granules of the regulated secretory pathway in AtT20 cells
    Title: Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells.
  8. SgIII knockdown impairs intracellular retention of chromogranin A and proopiomelanocortin in AtT-20 cells.
    Title: Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones.
  9. The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits.
    Title: Secretogranin III is an astrocyte granin that is overexpressed in reactive glia.
  10. SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
    Title: Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
secretogranin-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164790.1 → NP_001158262.1  secretogranin-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.
    Source sequence(s)
    AK139140, AK164089, BU058741
    Consensus CDS
    CCDS90627.1
    UniProtKB/Swiss-Prot
    P47867
    Related
    ENSMUSP00000149561.2, ENSMUST00000213324.2
    Conserved Domains (1) summary
    pfam15467
    Location:20 → 466
    SGIII; Secretogranin-3

  2. NM_009130.3 → NP_033156.1  secretogranin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK139140, BU058741
    Consensus CDS
    CCDS23347.1
    UniProtKB/Swiss-Prot
    P47867, Q3UTT1, Q3UZT8, Q8R1D7
    Related
    ENSMUSP00000034699.7, ENSMUST00000034699.8
    Conserved Domains (1) summary
    pfam15467
    Location:20 → 471
    SGIII; Secretogranin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75550648..75591733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313220.3 → XP_017168709.1  secretogranin-3 isoform X2

    Conserved Domains (1) summary
    pfam15467
    Location:29 → 433
    SGIII; Secretogranin-3

  2. XM_006510881.5 → XP_006510944.1  secretogranin-3 isoform X1

    Conserved Domains (1) summary
    pfam15467
    Location:29 → 438
    SGIII; Secretogranin-3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47867.1 GenPept UniProtKB/Swiss-Prot:P47867

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous