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Scg2 secretogranin II [ Mus musculus (house mouse) ]

Gene ID: 20254, updated on 5-Mar-2024

Summary

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Official Symbol
Scg2provided by MGI
Official Full Name
secretogranin IIprovided by MGI
Primary source
MGI:MGI:103033
See related
Ensembl:ENSMUSG00000050711 AllianceGenome:MGI:103033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chgc; SgII
Summary
Predicted to enable chemoattractant activity and cytokine activity. Involved in angiogenesis. Located in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCG2 (secretogranin II). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 52.5), cerebellum adult (RPKM 43.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 40.89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79412083..79417743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79434366..79440026, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 29536 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01438 Neighboring gene STARR-seq mESC enhancer starr_01439 Neighboring gene STARR-seq mESC enhancer starr_01440 Neighboring gene predicted gene, 57565 Neighboring gene STARR-seq mESC enhancer starr_01441 Neighboring gene STARR-seq mESC enhancer starr_01442 Neighboring gene STARR-seq mESC enhancer starr_01443 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene predicted gene, 24160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Excitotoxicity Alters Endogenous Secretoneurin Plasma Levels, but Supplementation with Secretoneurin Does Not Protect Against Excitotoxic Neonatal Brain Injury. Posod A, et al. Neuroscience, 2019 Jul 1. PMID 31121260
  2. The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. Iwase K, et al. J Neurochem, 2014 Jan. PMID 24111984
  3. Monocular enucleation profoundly reduces secretogranin II expression in adult mouse visual cortex. Paulussen M, et al. Neurochem Int, 2011 Dec. PMID 21945639
  4. Cellular expression and subcellular localization of secretogranin II in the mouse hippocampus and cerebellum. Miyazaki T, et al. Eur J Neurosci, 2011 Jan. PMID 21044184
  5. Secretoneurin promotes pertussis toxin-sensitive neurite outgrowth in cerebellar granule cells. Gasser MC, et al. J Neurochem, 2003 May. PMID 12694392

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
    Title: Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2.
  2. Endogenous secretoneurin plasma levels are lower in newborn animals subjected to an excitotoxic insult than in healthy controls.
    Title: Excitotoxicity Alters Endogenous Secretoneurin Plasma Levels, but Supplementation with Secretoneurin Does Not Protect Against Excitotoxic Neonatal Brain Injury.
  3. Scg2 is a major secretory target of REST with a cell differentiation-enhancing activity in neural stem cells.
    Title: REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.
  4. Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
    Title: Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF.
  5. Scg2 is a good candidate for the signal integrator required for activity-dependent plasticity such as associative learning and memory.
    Title: The secretogranin II gene is a signal integrator of glutamate and dopamine inputs.
  6. SgII binds directly to the secretory granule membrane and controls intracellular retention of proopiomelanocortin in AtT-20 cells.
    Title: Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones.
  7. SgII mRNA levels were 10.5 fold upregulated in the left ventricle of animals with myocardial infarction and heart failure.
    Title: Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties.
  8. it was proven that ScgII cannot be categorized as an activity marker, but more likely plays a role in visual system plasticity by modulating a range of neurotransmitters and neuropeptides
    Title: Monocular enucleation profoundly reduces secretogranin II expression in adult mouse visual cortex.
  9. SN activates the protein kinase A (PKA) and cAMP-induced ERK signaling pathways in the LH-secreting mouse LbetaT2 pituitary cell line
    Title: Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.
  10. The wide subcellular localization of secretogranin II in mouse brain may reflect diverse release sites of neuropeptides and secretorneurin, or suggests its role in the sorting and packaging of molecules other than neuropeptides in non-LDCV compartments.
    Title: Cellular expression and subcellular localization of secretogranin II in the mouse hippocampus and cerebellum.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in dense core granule IDA
Inferred from Direct Assay
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secretogranin-2
Names
chromogranin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310680.2 → NP_001297609.1  secretogranin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC083887
    Consensus CDS
    CCDS78625.1
    UniProtKB/TrEMBL
    Q4W8U9
    Related
    ENSMUSP00000139740.2, ENSMUST00000185234.2
    Conserved Domains (1) summary
    pfam01271
    Location:27 → 574
    Granin; Granin (chromogranin or secretogranin)

  2. NM_009129.3 → NP_033155.1  secretogranin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC083887
    Consensus CDS
    CCDS15089.1
    UniProtKB/Swiss-Prot
    Q03517, Q80Y79, Q9CW80
    Related
    ENSMUSP00000062556.5, ENSMUST00000049972.6
    Conserved Domains (1) summary
    pfam01271
    Location:27 → 614
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    79412083..79417743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03517.1 GenPept UniProtKB/Swiss-Prot:Q03517

Gene LinkOut

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