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Sars1 seryl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 20226, updated on 5-Mar-2024

Summary

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Official Symbol
Sars1provided by MGI
Official Full Name
seryl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:102809
See related
Ensembl:ENSMUSG00000068739 AllianceGenome:MGI:102809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sars; Strs; serRS
Summary
Predicted to enable several functions, including nucleic acid binding activity; protein homodimerization activity; and serine-tRNA ligase activity. Predicted to be involved in negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and seryl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 31.6), CNS E11.5 (RPKM 30.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F3; 3 47.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108332180..108352575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108424864..108445259, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08685 Neighboring gene STARR-positive B cell enhancer ABC_E2094 Neighboring gene proline/serine-rich coiled-coil 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene predicted gene, 52630 Neighboring gene STARR-seq mESC enhancer starr_08687 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108248013-108248314 Neighboring gene STARR-seq mESC enhancer starr_08688 Neighboring gene predicted gene, 22942 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator 1 Neighboring gene predicted gene, 23336 Neighboring gene STARR-seq mESC enhancer starr_08689 Neighboring gene STARR-positive B cell enhancer ABC_E4574 Neighboring gene cilia and flagella associated protein 276

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aminoacyl-tRNA synthetases: a family of expanding functions. Mittelwihr, France, October 10-15, 1999. Martinis SA, et al. EMBO J, 1999 Sep 1. PMID 10469639, Free PMC Article
  2. Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer. Zhao J, et al. Signal Transduct Target Ther, 2021 Aug 16. PMID 34400610, Free PMC Article
  3. Mammalian seryl-tRNA synthetase associates with mRNA in vivo and has homology to elongation factor 1 alpha. Miseta A, et al. J Biol Chem, 1991 Oct 15. PMID 1918033
  4. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Wei N, et al. Mol Cell, 2014 Oct 23. PMID 25284223, Free PMC Article
  5. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer.
    Title: Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables selenocysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in selenocysteine incorporation ISO
Inferred from Sequence Orthology
more info
  
involved_in seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine--tRNA ligase, cytoplasmic
Names
seryl-aminoacyl-tRNA synthetase 1
seryl-tRNA synthetase, cytoplasmic
seryl-tRNA(Ser/Sec) synthetase
NP_001191908.1
NP_035449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204979.1 → NP_001191908.1  serine--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001191908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK028358, AK075827, BP765728, BY034232
    Consensus CDS
    CCDS57254.1
    UniProtKB/Swiss-Prot
    A2AFR8, P26638
    UniProtKB/TrEMBL
    Q3U6F6
    Related
    ENSMUSP00000088041.6, ENSMUST00000090553.12
    Conserved Domains (3) summary
    PLN02678
    Location:3 → 486
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:152 → 460
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3 → 109
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  2. NM_011319.3 → NP_035449.1  serine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_035449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK028358, AK082793, BP765728, BY034232
    Consensus CDS
    CCDS17760.1
    UniProtKB/TrEMBL
    Q3U6F6, Q8C483
    Related
    ENSMUSP00000099685.5, ENSMUST00000102625.11
    Conserved Domains (3) summary
    PLN02678
    Location:3 → 510
    PLN02678; seryl-tRNA synthetase
    cd00770
    Location:152 → 484
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    pfam02403
    Location:3 → 109
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108332180..108352575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26638.3 GenPept UniProtKB/Swiss-Prot:P26638

Gene LinkOut

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