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Sf3a2 splicing factor 3a, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 20222, updated on 5-Mar-2024

Summary

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Official Symbol
Sf3a2provided by MGI
Official Full Name
splicing factor 3a, subunit 2provided by MGI
Primary source
MGI:MGI:104912
See related
Ensembl:ENSMUSG00000020211 AllianceGenome:MGI:104912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
66kDa; PRP11; SFA66; Sap62
Summary
Predicted to be involved in U2-type prespliceosome assembly and positive regulation of neuron projection development. Predicted to act upstream of or within RNA splicing, via transesterification reactions. Part of U2 snRNP. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 42.2), ovary adult (RPKM 32.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80634569..80640756)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80798735..80804922)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_27297 Neighboring gene VISTA enhancer mm200 Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional analysis of the candidate spermatogenesis gene Ube1y and of the closely related Ube1x shows that they are coexpressed in spermatogonia and spermatids but are repressed in pachytene spermatocytes. Odorisio T, et al. Dev Biol, 1996 Nov 25. PMID 8948595
  2. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Swain A, et al. Nat Genet, 1996 Apr. PMID 8630494
  3. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions. Maitra R, et al. Nucleic Acids Res, 2009 Jun. PMID 19324890, Free PMC Article
  4. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. Dresser DW, et al. Gene, 2001 Oct 17. PMID 11602354
  5. The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous. Dresser DW, et al. Hum Mol Genet, 1995 Sep. PMID 8541848

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing, via transesterification reactions TAS
Traceable Author Statement
more info
 PubMed 
involved_in U2-type prespliceosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
splicing factor 3A subunit 2
Names
SAP 62
SF3a66
spliceosomal protein gene 62
spliceosome-associated protein 62
splicing factor 3a, subunit 2, 66kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013651.4 → NP_038679.3  splicing factor 3A subunit 2

    See identical proteins and their annotated locations for NP_038679.3

    Status: VALIDATED

    Source sequence(s)
    BC052697, CX212776, CX214888
    Consensus CDS
    CCDS35986.2
    UniProtKB/TrEMBL
    G3UVU2
    Related
    ENSMUSP00000117160.2, ENSMUST00000148665.8
    Conserved Domains (2) summary
    COG5246
    Location:1 → 217
    PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
    cl26386
    Location:324 → 449
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80634569..80640756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62203.2 GenPept UniProtKB/Swiss-Prot:Q62203

Gene LinkOut

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