Apcs amyloid P component, serum [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apcsprovided by MGI
Official Full Name: amyloid P component, serumprovided by MGI
Primary source: MGI:MGI:98229
See related: Ensembl:ENSMUSG00000026542 AllianceGenome:MGI:98229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sap
Summary: Predicted to enable several functions, including complement component C1q complex binding activity; low-density lipoprotein particle binding activity; and virion binding activity. Predicted to be involved in several processes, including complement activation, classical pathway; modulation by host of viral process; and negative regulation of monocyte differentiation. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in amyloidosis. Orthologous to human APCS (amyloid P component, serum). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver E18 (RPKM 530.3) See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 80.33 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172721528..172722516, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172893961..172895054, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.
Title: SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.
Title: Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.
SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines
Title: SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice.
Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.
Title: DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation
Title: FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.
Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene.
Title: Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene.
binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis
Title: Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
SAP has an effect on macrophages in fibrotic lung disease
Title: Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.
sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis.
Title: Transgenic mice overexpressing secreted frizzled-related proteins (sFRP)4 under the control of serum amyloid P promoter exhibit low bone mass but did not result in disturbed phosphate homeostasis.
Serum amyloid P is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis.
Title: Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sap (e-PCR), detects polymorphism
- UniSTS:144368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum amyloid P-component

Names: APCS amyloid P-component serum protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.