Acsm3 acyl-CoA synthetase medium-chain family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acsm3provided by MGI
Official Full Name: acyl-CoA synthetase medium-chain family member 3provided by MGI
Primary source: MGI:MGI:99538
See related: Ensembl:ENSMUSG00000030935 AllianceGenome:MGI:99538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sa; Sah
Summary: Enables butyrate-CoA ligase activity; fatty acid ligase activity; and propionate CoA-transferase activity. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrial matrix. Is expressed in alimentary system; integumental system; and lower urinary tract. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 13.3), liver adult (RPKM 7.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 64.17 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (119360106..119384119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (119760883..119784896)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4alpha-p38 MAPK axis.
Title: Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4α-p38 MAPK axis.
Data suggest that expression of Acsm3 in adipose tissue can be regulated by dietary factors; here, expression of Acsm3 in white adipose tissue is down-regulated in obesity caused by high-fat diet.
Title: High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes.
Analysis of the role of the SA gene in blood pressure regulation.
Title: Analysis of the role of the SA gene in blood pressure regulation by gene targeting.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

G67046 (e-PCR)
- UniSTS:178255

BE108110 (e-PCR)
- UniSTS:247646

NoName (e-PCR)
- UniSTS:235765

NoName (e-PCR)
- UniSTS:235768

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables butyrate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables butyrate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables butyrate-CoA ligase activity	TAS Traceable Author Statement more info
enables fatty acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty-acyl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionate CoA-transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables propionate-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A synthetase ACSM3, mitochondrial

Names: SA hypertension-associated homolog; butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3; middle-chain acyl-CoA synthetase 3; propionate--CoA ligase; protein SA homolog

NP_058566.3

EC 6.2.1.17

EC 6.2.1.2

NP_997606.2

EC 6.2.1.17

EC 6.2.1.2

NP_997607.2

EC 6.2.1.17

EC 6.2.1.2

XP_006507538.1

EC 6.2.1.17

EC 6.2.1.2

XP_017177549.1

EC 6.2.1.17

EC 6.2.1.2

XP_017177550.1

EC 6.2.1.17

EC 6.2.1.2

XP_017177551.1

EC 6.2.1.17

EC 6.2.1.2

XP_017177552.1

EC 6.2.1.17

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016870.4 → NP_058566.3 acyl-coenzyme A synthetase ACSM3, mitochondrial

See identical proteins and their annotated locations for NP_058566.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcripts. The three transcript variants all encode the same protein.

Source sequence(s)

AC164158

Consensus CDS

CCDS21786.1

UniProtKB/Swiss-Prot

Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0

Related

ENSMUSP00000102138.2, ENSMUST00000106528.8

Conserved Domains (1) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
NM_212441.3 → NP_997606.2 acyl-coenzyme A synthetase ACSM3, mitochondrial

See identical proteins and their annotated locations for NP_997606.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' UTR, compared to variant 1. The three transcript variants all encode the same protein.

Source sequence(s)

AC164158

Consensus CDS

CCDS21786.1

UniProtKB/Swiss-Prot

Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0

Related

ENSMUSP00000068803.4, ENSMUST00000063770.10

Conserved Domains (1) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
NM_212442.3 → NP_997607.2 acyl-coenzyme A synthetase ACSM3, mitochondrial

See identical proteins and their annotated locations for NP_997607.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate in-frame segment in the 5' UTR, compared to variant 1. The three transcript variants all encode the same protein.

Source sequence(s)

AC164158

Consensus CDS

CCDS21786.1

UniProtKB/Swiss-Prot

Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0

Related

ENSMUSP00000102137.2, ENSMUST00000106527.8

Conserved Domains (1) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

119360106..119384119

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322060.2 → XP_017177549.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

Conserved Domains (1) summary

cl17068
Location:48 → 554

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_017322063.2 → XP_017177552.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X3

Conserved Domains (1) summary

cd05928
Location:48 → 578

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
XM_006507475.4 → XP_006507538.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006507538.1

Conserved Domains (1) summary

cl17068
Location:48 → 553

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_017322061.3 → XP_017177550.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

Conserved Domains (1) summary

cl17068
Location:48 → 554

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_017322062.2 → XP_017177551.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

Conserved Domains (1) summary

cl17068
Location:48 → 554

AFD_class_I; Adenylate forming domain, Class I superfamily