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Saa1 serum amyloid A 1 [ Mus musculus (house mouse) ]

Gene ID: 20208, updated on 3-Apr-2024

Summary

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Official Symbol
Saa1provided by MGI
Official Full Name
serum amyloid A 1provided by MGI
Primary source
MGI:MGI:98221
See related
Ensembl:ENSMUSG00000074115 AllianceGenome:MGI:98221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Saa2; Saa-1
Summary
Predicted to enable heparin binding activity. Acts upstream of or within cholesterol metabolic process and response to bacterium. Located in extracellular space. Is expressed in intestinal villus; large intestine epithelium; liver; and small intestine epithelium. Orthologous to human SAA2 (serum amyloid A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 137.3), large intestine adult (RPKM 79.1) and 1 other tissue See more
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Genomic context

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Location:
7 B3; 7 30.54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46389921..46392404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46740497..46743181, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serum amyloid A 4 Neighboring gene serum amyloid A, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18868 Neighboring gene serum amyloid A 2 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene STARR-seq mESC enhancer starr_18870 Neighboring gene STARR-positive B cell enhancer ABC_E6548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-κB/p38/JNK and TGFβ/Smad pathways. Xiao Y, et al. FASEB J, 2023 May. PMID 37022639
  2. Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1. Lv Z, et al. Mol Pharm, 2022 Nov 7. PMID 36173129
  3. Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding. Heerde T, et al. Nat Commun, 2022 Jan 10. PMID 35013242, Free PMC Article
  4. Hepatocytes derived increased SAA1 promotes intrahepatic platelet aggregation and aggravates liver inflammation in NAFLD. Li D, et al. Biochem Biophys Res Commun, 2021 May 28. PMID 33813276
  5. Serum amyloid A1 is involved in amyloid plaque aggregation and memory decline in amyloid beta abundant condition. Jang S, et al. Transgenic Res, 2019 Dec. PMID 31407125

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAA1 exacerbates pancreatic beta-cell dysfunction through activation of NF-kappaB signaling in high-fat diet-induced type 2 diabetes mice.
    Title: SAA1 exacerbates pancreatic β-cell dysfunction through activation of NF-κB signaling in high-fat diet-induced type 2 diabetes mice.
  2. SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-kappaB/p38/JNK and TGFbeta/Smad pathways.
    Title: SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-κB/p38/JNK and TGFβ/Smad pathways.
  3. Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
    Title: Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
  4. Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1.
    Title: Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1.
  5. Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-kappaB signaling pathway.
    Title: Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway.
  6. Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
    Title: Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
  7. Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice.
    Title: Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice.
  8. SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
    Title: SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
  9. Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
    Title: Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
  10. Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density.
    Title: Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serum amyloid A-1 protein
Names
serum amyloid A 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357493.1 → NP_001344422.1  serum amyloid A-1 protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC090122
    Consensus CDS
    CCDS21284.1
    UniProtKB/Swiss-Prot
    P05366
    UniProtKB/TrEMBL
    Q5I0U6, Q64454, Q8R3T4
    Conserved Domains (1) summary
    pfam00277
    Location:23 → 122
    SAA; Serum amyloid A protein

  2. NM_001403085.1 → NP_001390014.1  serum amyloid A-1 protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC090122
    UniProtKB/Swiss-Prot
    P05366
    UniProtKB/TrEMBL
    Q5I0U6

  3. NM_001403086.1 → NP_001390015.1  serum amyloid A-1 protein precursor

    Status: VALIDATED

    Source sequence(s)
    AC090122
    UniProtKB/Swiss-Prot
    P05366
    UniProtKB/TrEMBL
    Q5I0U6

  4. NM_009117.4 → NP_033143.1  serum amyloid A-1 protein precursor

    See identical proteins and their annotated locations for NP_033143.1

    Status: VALIDATED

    Source sequence(s)
    AC090122
    Consensus CDS
    CCDS21284.1
    UniProtKB/Swiss-Prot
    P05366
    UniProtKB/TrEMBL
    Q5I0U6, Q64454, Q8R3T4
    Related
    ENSMUSP00000119150.2, ENSMUST00000128088.4
    Conserved Domains (1) summary
    pfam00277
    Location:23 → 122
    SAA; Serum amyloid A protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46389921..46392404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05366.2 GenPept UniProtKB/Swiss-Prot:P05366

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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