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S100a5 S100 calcium binding protein A5 [ Mus musculus (house mouse) ]

Gene ID: 20199, updated on 5-Mar-2024

Summary

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Official Symbol
S100a5provided by MGI
Official Full Name
S100 calcium binding protein A5provided by MGI
Primary source
MGI:MGI:1338915
See related
Ensembl:ENSMUSG00000001023 AllianceGenome:MGI:1338915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S100D9
Summary
Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and protein homodimerization activity. Located in neuronal cell body. Orthologous to human S100A5 (S100 calcium binding protein A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward frontal lobe adult (RPKM 22.2) See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90513787..90519091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90606480..90611784)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A3 Neighboring gene STARR-seq mESC enhancer starr_08292 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium binding protein A4 Neighboring gene STARR-positive B cell enhancer ABC_E6073 Neighboring gene predicted gene, 57853 Neighboring gene S100 calcium binding protein A6 (calcyclin) Neighboring gene STARR-seq mESC enhancer starr_08293 Neighboring gene predicted gene, 19739

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activity-dependent genes in mouse olfactory sensory neurons. Fischl AM, et al. Chem Senses, 2014 Jun. PMID 24692514, Free PMC Article
  2. In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. McClintock TS, et al. J Neurosci, 2014 Nov 19. PMID 25411495, Free PMC Article
  3. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
  4. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Donato R. Biochim Biophys Acta, 1999 Jul 8. PMID 10395934
  5. Clustered organization of S100 genes in human and mouse. Ridinger K, et al. Biochim Biophys Acta, 1998 Dec 10. PMID 9920416

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein S100-A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410573.1 → NP_001397502.1  protein S100-A5

    Status: VALIDATED

    Source sequence(s)
    AC160552
    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2

  2. NM_001410574.1 → NP_001397503.1  protein S100-A5

    Status: VALIDATED

    Source sequence(s)
    AC160552
    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2

  3. NM_001410575.1 → NP_001397504.1  protein S100-A5

    Status: VALIDATED

    Source sequence(s)
    AC160552
    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2

  4. NM_001410576.1 → NP_001397505.1  protein S100-A5

    Status: VALIDATED

    Source sequence(s)
    AC160552
    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2

  5. NM_011312.3 → NP_035442.1  protein S100-A5

    See identical proteins and their annotated locations for NP_035442.1

    Status: VALIDATED

    Source sequence(s)
    AC160552
    Consensus CDS
    CCDS38505.1
    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2
    Related
    ENSMUSP00000102952.2, ENSMUST00000107329.8
    Conserved Domains (1) summary
    cd00213
    Location:3 → 88
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90513787..90519091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162969.1 → XP_036018862.1  protein S100-A5 isoform X1

    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2
    Conserved Domains (1) summary
    cd00213
    Location:3 → 88
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

  2. XM_036162970.1 → XP_036018863.1  protein S100-A5 isoform X1

    UniProtKB/Swiss-Prot
    O88945, P63084, P82540
    UniProtKB/TrEMBL
    Q149U2
    Related
    ENSMUSP00000001049.5, ENSMUST00000001049.5
    Conserved Domains (1) summary
    cd00213
    Location:3 → 88
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63084.1 GenPept UniProtKB/Swiss-Prot:P63084

Gene LinkOut

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