S100a11 S100 calcium binding protein A11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a11provided by MGI
Official Full Name: S100 calcium binding protein A11provided by MGI
Primary source: MGI:MGI:1338798
See related: Ensembl:ENSMUSG00000027907 AllianceGenome:MGI:1338798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cal; EMAPI; Emap1; S100c; S100a14
Summary: Predicted to enable several functions, including S100 protein binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in positive regulation of smooth muscle cell migration. Located in cytoplasm. Is expressed in several structures, including gonad; heart and pericardium; lung; pancreas mesenchyme; and thymus. Orthologous to human S100A11 (S100 calcium binding protein A11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 206.5), subcutaneous fat pad adult (RPKM 172.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.51 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (93427803..93433595)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (93520496..93526288)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Title: S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Dicalcin suppresses in vitro trophoblast attachment in human cell lines.
Title: Dicalcin suppresses in vitro trophoblast attachment in human cell lines.
this study shows that alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii
Title: Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.
Endometrial S100A11 is a crucial intermediator in EGF-stimulated embryo adhesion, endometrium receptivity, and immunotolerance via affecting Ca2+ uptake and release from intracellular Ca2+ stores.
Title: Down-regulation of S100A11, a calcium-binding protein, in human endometrium may cause reproductive failure.
S100A11 is the mouse counterpart of Xenopus dicalcin that suppresses the fertilization process through its action on cumulus cells, and thereby plays a key role in fertilization success in the mouse.
Title: Characterization of S100A11, a suppressive factor of fertilization, in the mouse female reproductive tract.
Following transformation by transglutaminase 2, S100A11 acquires the capacity to signal through the p38 MAP kinase pathway, accelerate chondrocyte hypertrophy, and couple inflammation with chondrocyte activation to promote progression of osteoarthritis.
Title: Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

S100a11 (e-PCR), detects polymorphism
- UniSTS:498776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A11

Names: EMAP; S100 calcium binding protein A14; calgizzarin; calizzarin; endothelial monocyte activating polypeptide 1; endothelial monocyte-activating polypeptide; protein S100-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016740.3 → NP_058020.1 protein S100-A11

See identical proteins and their annotated locations for NP_058020.1

Status: VALIDATED

Source sequence(s)

AA207524, AK164352

Consensus CDS

CCDS38525.1

UniProtKB/Swiss-Prot

P50543, Q545S1

Related

ENSMUSP00000029515.5, ENSMUST00000029515.5

Conserved Domains (1) summary

cd05023
Location:2 → 90

S-100A11; S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100 EF-hand ...