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Ryr3 ryanodine receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 20192, updated on 21-Apr-2024

Summary

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Official Symbol
Ryr3provided by MGI
Official Full Name
ryanodine receptor 3provided by MGI
Primary source
MGI:MGI:99684
See related
Ensembl:ENSMUSG00000057378 AllianceGenome:MGI:99684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RYR-3; C230090H21
Summary
Predicted to enable calcium ion binding activity; calcium-induced calcium release activity; and ryanodine-sensitive calcium-release channel activity. Acts upstream of or within cellular calcium ion homeostasis and striated muscle contraction. Located in sarcoplasmic reticulum membrane. Part of junctional membrane complex. Is expressed in several structures, including central nervous system; diaphragm; hemolymphoid system; liver; and musculature. Orthologous to human RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.5), bladder adult (RPKM 2.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E3- E4; 2 57.2 cM
Exon count:
106
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112461699..113047755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112631354..113217405, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene STARR-positive B cell enhancer ABC_E4487 Neighboring gene STARR-seq mESC enhancer starr_05388 Neighboring gene predicted gene, 22676 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112443695-112443995 Neighboring gene apoptosis, caspase activation inhibitor Neighboring gene STARR-seq mESC enhancer starr_05389 Neighboring gene STARR-seq mESC enhancer starr_05390 Neighboring gene STARR-seq mESC enhancer starr_05392 Neighboring gene STARR-seq mESC enhancer starr_05393 Neighboring gene STARR-seq mESC enhancer starr_05394 Neighboring gene STARR-seq mESC enhancer starr_05395 Neighboring gene STARR-seq mESC enhancer starr_05396 Neighboring gene predicted gene, 26505 Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene STARR-seq mESC enhancer starr_05397 Neighboring gene STARR-seq mESC enhancer starr_05399 Neighboring gene formin 1 Neighboring gene STARR-seq mESC enhancer starr_05401 Neighboring gene predicted gene, 54142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3. Torres RF, et al. Neural Plast, 2021. PMID 34434232, Free PMC Article
  2. Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons. Tedoldi A, et al. PLoS One, 2020. PMID 32559219, Free PMC Article
  3. Extraocular muscle function is impaired in ryr3 (-/-) mice. Eckhardt J, et al. J Gen Physiol, 2019 Jul 1. PMID 31085573, Free PMC Article
  4. Negative regulation of cellular Ca(2+) mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle. Matsuki K, et al. Am J Physiol Cell Physiol, 2018 Jul 1. PMID 29537866
  5. Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy. Matsuki K, et al. Pflugers Arch, 2017 Feb. PMID 27866274

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3.
    Title: Spatial Learning Is Associated with Antagonist Outcomes for DNA Methylation and DNA Hydroxymethylation in the Transcriptional Regulation of the Ryanodine Receptor 3.
  2. Extraocular muscle function is impaired in ryr3 (-/-) mice.
    Title: Extraocular muscle function is impaired in ryr3 (-/-) mice.
  3. calsenilin controls the activity of neuronal RyRs.
    Title: Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.
  4. Deletion of RyanR3 increased hippocampal neuronal network excitability and accelerated Alzheimer disease pathology.
    Title: The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.
  5. Data indicate that TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR.
    Title: Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor.
  6. knockdown of RyR1-3 expression in wild-type hippocampal neurons to levels comparable with the RyR protein reduction in presenilin-deficient hippocampal neurons mimics the defects exhibited in calcium homeostasis and presynaptic function
    Title: Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
  7. Silencing of RyR3 expression in 3T3-L1 preadipocytes resulted in up-regulated adiponectin promoter activity, enhanced adiponectin mRNA expression, and more adiponectin protein secreted into the medium.
    Title: Knockdown of RyR3 enhances adiponectin expression through an atf3-dependent pathway.
  8. A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated
    Title: Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.
  9. Report heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
    Title: Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
  10. Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules
    Title: Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-induced calcium release activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of junctional membrane complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ryanodine receptor 3
Names
brain ryanodine receptor-calcium release channel
brain-type ryanodine receptor
calcium release channel
type 3 ryanodine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319156.1 → NP_001306085.1  ryanodine receptor 3

    Status: VALIDATED

    Source sequence(s)
    AI851294, AK082701, AL672250, AL691423, AL732316, CJ060048
    Consensus CDS
    CCDS50661.2
    UniProtKB/TrEMBL
    A0A140LJF7, A0A140LJK7
    Related
    ENSMUSP00000147250.2, ENSMUST00000208290.2
    Conserved Domains (12) summary
    smart00472
    Location:275 → 368
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:641 → 792
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1072 → 1204
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4619 → 4779
    Ion_trans; Ion transport protein
    pfam01365
    Location:442 → 621
    RYDR_ITPR; RIH domain
    pfam02026
    Location:849 → 937
    RyR; RyR domain
    pfam02815
    Location:216 → 397
    MIR; MIR domain
    pfam06459
    Location:4232 → 4502
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3729 → 3842
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:3933 → 3981
    EF-hand_8; EF-hand domain pair
    cd12879
    Location:1324 → 1462
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    cl19745
    Location:10 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112461699..113047755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316702.3 → XP_017172191.1  ryanodine receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A140LJF7
    Conserved Domains (11) summary
    cd12877
    Location:667 → 818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1099 → 1231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1351 → 1489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4641 → 4801
    Ion_trans; Ion transport protein
    pfam01365
    Location:451 → 632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875 → 963
    RyR; RyR domain
    pfam02815
    Location:227 → 408
    MIR; MIR domain
    pfam06459
    Location:4254 → 4524
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3751 → 3864
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:3955 → 4003
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14 → 218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  2. XM_017316700.3 → XP_017172189.1  ryanodine receptor 3 isoform X1

    UniProtKB/TrEMBL
    A0A140LJF7
    Conserved Domains (11) summary
    cd12877
    Location:667 → 818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1099 → 1231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1351 → 1489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4646 → 4806
    Ion_trans; Ion transport protein
    pfam01365
    Location:451 → 632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875 → 963
    RyR; RyR domain
    pfam02815
    Location:227 → 408
    MIR; MIR domain
    pfam06459
    Location:4259 → 4529
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3756 → 3869
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:3960 → 4008
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14 → 218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  3. XM_017316705.3 → XP_017172194.1  ryanodine receptor 3 isoform X3

    UniProtKB/Swiss-Prot
    A2AGL3, P70184, P70185, Q3V1H0, Q4JFC4, Q60836, Q62175, Q62198, Q9QY91
    UniProtKB/TrEMBL
    A0A140LJF7
    Related
    ENSMUSP00000079503.6, ENSMUST00000080673.13
    Conserved Domains (11) summary
    cd12877
    Location:641 → 792
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1072 → 1204
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1324 → 1462
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:4614 → 4774
    Ion_trans; Ion transport protein
    pfam01365
    Location:440 → 621
    RYDR_ITPR; RIH domain
    pfam02026
    Location:849 → 937
    RyR; RyR domain
    pfam02815
    Location:216 → 397
    MIR; MIR domain
    pfam06459
    Location:4227 → 4497
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3724 → 3837
    RIH_assoc; RyR and IP3R Homology associated
    pfam13833
    Location:3928 → 3976
    EF-hand_8; EF-hand domain pair
    cl19745
    Location:14 → 207
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

  4. XM_017316709.3 → XP_017172198.1  ryanodine receptor 3 isoform X4

    Conserved Domains (7) summary
    cd12877
    Location:667 → 818
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1099 → 1231
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:1351 → 1489
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam01365
    Location:451 → 632
    RYDR_ITPR; RIH domain
    pfam02026
    Location:875 → 963
    RyR; RyR domain
    pfam02815
    Location:227 → 408
    MIR; MIR domain
    cl19745
    Location:14 → 218
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RNA

  1. XR_004939164.1 RNA Sequence

  2. XR_004939166.1 RNA Sequence

  3. XR_003951556.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177652.2: Suppressed sequence

    Description
    NM_177652.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AGL3.1 GenPept UniProtKB/Swiss-Prot:A2AGL3

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