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Dhrs3 dehydrogenase/reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 20148, updated on 21-Apr-2024

Summary

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Official Symbol
Dhrs3provided by MGI
Official Full Name
dehydrogenase/reductase 3provided by MGI
Primary source
MGI:MGI:1315215
See related
Ensembl:ENSMUSG00000066026 AllianceGenome:MGI:1315215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsdr1; retSDR1
Summary
Enables NAD-retinol dehydrogenase activity. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 53.4), bladder adult (RPKM 42.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E1; 4 78.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144618712..144654214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (144892534..144928209)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11990 Neighboring gene STARR-seq mESC enhancer starr_11991 Neighboring gene peroxiredoxin 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11992 Neighboring gene predicted gene, 46890 Neighboring gene STARR-seq mESC enhancer starr_11993 Neighboring gene STARR-positive B cell enhancer ABC_E8006 Neighboring gene STARR-positive B cell enhancer ABC_E10275 Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 42344 Neighboring gene predicted gene, 36317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. Haeseleer F, et al. J Biol Chem, 1998 Aug 21. PMID 9705317
  2. Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes. Klyuyeva AV, et al. J Biol Chem, 2021 Jan-Jun. PMID 33485967, Free PMC Article
  3. Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature. Wang S, et al. Dev Dyn, 2018 Aug. PMID 29806219, Free PMC Article
  4. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. Deisenroth C, et al. J Biol Chem, 2011 Aug 12. PMID 21659514, Free PMC Article
  5. Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Bächner D, et al. Dev Dyn, 1998 Dec. PMID 9853961

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
    Title: Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
  2. Epicardial upregulation of DHRS3 gene Results in Defective Coronary Vessel Development.
    Title: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
  3. Yap targets Dhrs3, to reduce retinoic acid synthesis and inhibit cardiac fibroblast differentiation during development.
    Title: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
  4. Dhrs3 plays critical roles in the development of the heart and the coronary vasculature by controlling the formation of retinoic acid.
    Title: Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
  5. DHRS3 is important in limiting the formation of retinoic acid to ensure the proper development of the coronary vasculature.
    Title: Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
  6. DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. Lack of DHRS3 leads to increases in the levels of retinoic acid, decreases in the levels of retinol and retinyl esters and changes in the expression of genes regulated by retinoic acid. As a result, Dhrs3-deficient embryos exhibit defects in the development of the heart, palate and skeleton and are not viable.
    Title: The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.
  7. Reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development.
    Title: The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.
  8. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.
    Title: p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinoid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short-chain dehydrogenase/reductase 3
Names
dehydrogenase/reductase (SDR family) member 3
retinal short-chain dehydrogenase/reductase 1
NP_001165895.1
NP_001344203.1
NP_001344204.2
NP_001344205.2
NP_001344206.1
NP_001411778.1
NP_001411779.1
NP_001411780.1
NP_001411781.1
NP_035433.1
XP_006538744.1
XP_030109228.1
XP_036019818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172424.3 → NP_001165895.1  short-chain dehydrogenase/reductase 3 isoform 2

    See identical proteins and their annotated locations for NP_001165895.1

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS51368.1
    UniProtKB/TrEMBL
    G5E8W9
    Related
    ENSMUSP00000126154.2, ENSMUST00000171001.8
    Conserved Domains (1) summary
    cd05339
    Location:27 → 255
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

  2. NM_001357274.2 → NP_001344203.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS51368.1
    UniProtKB/TrEMBL
    G5E8W9
    Conserved Domains (1) summary
    cd05339
    Location:27 → 255
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

  3. NM_001357275.2 → NP_001344204.2  short-chain dehydrogenase/reductase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  4. NM_001357276.2 → NP_001344205.2  short-chain dehydrogenase/reductase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  5. NM_001357277.2 → NP_001344206.1  short-chain dehydrogenase/reductase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Conserved Domains (1) summary
    cd05339
    Location:1 → 196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

  6. NM_001424849.1 → NP_001411778.1  short-chain dehydrogenase/reductase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  7. NM_001424850.1 → NP_001411779.1  short-chain dehydrogenase/reductase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  8. NM_001424851.1 → NP_001411780.1  short-chain dehydrogenase/reductase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  9. NM_001424852.1 → NP_001411781.1  short-chain dehydrogenase/reductase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773

  10. NM_011303.8 → NP_035433.1  short-chain dehydrogenase/reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_035433.1

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS18912.1
    UniProtKB/Swiss-Prot
    O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6
    Related
    ENSMUSP00000122552.2, ENSMUST00000154208.8
    Conserved Domains (2) summary
    cd05339
    Location:53 → 281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    PRK09072
    Location:35 → 288
    PRK09072; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    144618712..144654214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253368.2 → XP_030109228.1  short-chain dehydrogenase/reductase 3 isoform X2

    Conserved Domains (1) summary
    cd05339
    Location:48 → 216
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

  2. XM_006538681.5 → XP_006538744.1  short-chain dehydrogenase/reductase 3 isoform X2

    See identical proteins and their annotated locations for XP_006538744.1

    Conserved Domains (1) summary
    cd05339
    Location:48 → 216
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

  3. XM_036163925.1 → XP_036019818.1  short-chain dehydrogenase/reductase 3 isoform X1

    Conserved Domains (1) summary
    cd05339
    Location:53 → 233
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88876.2 GenPept UniProtKB/Swiss-Prot:O88876

Gene LinkOut

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