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FBXO15 F-box protein 15 [ Homo sapiens (human) ]

Gene ID: 201456, updated on 5-Mar-2024

Summary

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Official Symbol
FBXO15provided by HGNC
Official Full Name
F-box protein 15provided by HGNC
Primary source
HGNC:HGNC:13617
See related
Ensembl:ENSG00000141665 MIM:609093; AllianceGenome:HGNC:13617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX15
Summary
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 2.7), kidney (RPKM 0.4) and 3 other tissues See more
Orthologs
mouse all
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Genomic context

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See FBXO15 in Genome Data Viewer
Location:
18q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (74073368..74147834, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (74294328..74368800, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (71740603..71815069, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372191 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:71510186-71510359 Neighboring gene uncharacterized LOC124904358 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50059 Neighboring gene Sharpr-MPRA regulatory region 9472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13493 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71817752-71818951 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71822138-71823337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13494 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50247 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:71864836-71865492 Neighboring gene RNA, 7SL, cytoplasmic 551, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression. Zhao Y, et al. Signal Transduct Target Ther, 2021 Jun 4. PMID 34083507, Free PMC Article
  2. FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells. Katayama K, et al. Cancer Sci, 2013 Jun. PMID 23465077, Free PMC Article
  3. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Chen BB, et al. Cell Rep, 2014 Apr 24. PMID 24703837, Free PMC Article
  4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
  5. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. Clijsters L, et al. Mol Cell, 2019 Jun 20. PMID 31130363, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression.
    Title: FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression.
  2. These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
    Title: FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of sleep habits and insomnia.
EBI GWAS Catalog
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
EBI GWAS Catalog
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
EBI GWAS Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC39671

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
F-box only protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142958.2 → NP_001136430.1  F-box only protein 15 isoform 2

    See identical proteins and their annotated locations for NP_001136430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094215, BU729305, DB447209
    Consensus CDS
    CCDS45884.1
    UniProtKB/Swiss-Prot
    B3KST3, Q8NCQ5
    Related
    ENSP00000393154.2, ENST00000419743.7
    Conserved Domains (1) summary
    pfam12937
    Location:74 → 118
    F-box-like; F-box-like

  2. NM_152676.3 → NP_689889.1  F-box only protein 15 isoform 1

    See identical proteins and their annotated locations for NP_689889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC084702, BC029579, BI829755, BU729305
    Conserved Domains (1) summary
    pfam12937
    Location:2 → 42
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    74073368..74147834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525856.2 → XP_011524158.1  F-box only protein 15 isoform X1

    Conserved Domains (1) summary
    pfam12937
    Location:74 → 118
    F-box-like; F-box-like

  2. XM_047437341.1 → XP_047293297.1  F-box only protein 15 isoform X3

  3. XM_047437342.1 → XP_047293298.1  F-box only protein 15 isoform X3

  4. XM_017025604.3 → XP_016881093.1  F-box only protein 15 isoform X3

    Conserved Domains (1) summary
    pfam12937
    Location:2 → 42
    F-box-like; F-box-like

  5. XM_011525860.1 → XP_011524162.1  F-box only protein 15 isoform X6

    Conserved Domains (1) summary
    pfam12937
    Location:74 → 118
    F-box-like; F-box-like

  6. XM_024451099.2 → XP_024306867.1  F-box only protein 15 isoform X2

    Conserved Domains (1) summary
    pfam12937
    Location:74 → 118
    F-box-like

  7. XM_047437343.1 → XP_047293299.1  F-box only protein 15 isoform X5

  8. XM_011525858.2 → XP_011524160.1  F-box only protein 15 isoform X4

    Conserved Domains (1) summary
    pfam12937
    Location:74 → 118
    F-box-like; F-box-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    74294328..74368800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318265.1 → XP_054174240.1  F-box only protein 15 isoform X1

  2. XM_054318268.1 → XP_054174243.1  F-box only protein 15 isoform X3

  3. XM_054318269.1 → XP_054174244.1  F-box only protein 15 isoform X3

  4. XM_054318267.1 → XP_054174242.1  F-box only protein 15 isoform X3

  5. XM_054318272.1 → XP_054174247.1  F-box only protein 15 isoform X6

  6. XM_054318266.1 → XP_054174241.1  F-box only protein 15 isoform X2

  7. XM_054318271.1 → XP_054174246.1  F-box only protein 15 isoform X5

  8. XM_054318270.1 → XP_054174245.1  F-box only protein 15 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCQ5.2 GenPept UniProtKB/Swiss-Prot:Q8NCQ5

Gene LinkOut

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