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SPEM2 SPEM family member 2 [ Homo sapiens (human) ]

Gene ID: 201243, updated on 5-Mar-2024

Summary

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Official Symbol
SPEM2provided by HGNC
Official Full Name
SPEM family member 2provided by HGNC
Primary source
HGNC:HGNC:27315
See related
Ensembl:ENSG00000184560 AllianceGenome:HGNC:27315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf74
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 18.5) See more
Orthologs
mouse all
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Genomic context

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See SPEM2 in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7425616..7427568)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7329669..7331621)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7328935..7330887)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8116 Neighboring gene neuroligin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646 Neighboring gene spermatid maturation 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7329870-7330371 Neighboring gene SPEM family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7339659-7340568 Neighboring gene transmembrane protein 102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein SPEM2
Names
uncharacterized protein C17orf74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175734.5 → NP_783861.3  uncharacterized protein SPEM2

    See identical proteins and their annotated locations for NP_783861.3

    Status: VALIDATED

    Source sequence(s)
    BC031286, BC044816
    Consensus CDS
    CCDS42255.1
    UniProtKB/Swiss-Prot
    Q0P670
    Related
    ENSP00000328061.3, ENST00000333870.8
    Conserved Domains (1) summary
    pfam15670
    Location:1 → 258
    Spem1; Spermatid maturation protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7425616..7427568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721471.4 → XP_006721534.1  uncharacterized protein SPEM2 isoform X1

    Conserved Domains (1) summary
    pfam15670
    Location:1 → 161
    Spem1; Spermatid maturation protein 1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p14 PATCHES

    Range
    46073..48025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332014.1 → XP_054187989.1  uncharacterized protein SPEM2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7329669..7331621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315367.1 → XP_054171342.1  uncharacterized protein SPEM2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P670.2 GenPept UniProtKB/Swiss-Prot:Q0P670

Gene LinkOut

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