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EMP1 epithelial membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 2012, updated on 5-Mar-2024

Summary

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Official Symbol
EMP1provided by HGNC
Official Full Name
epithelial membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:3333
See related
Ensembl:ENSG00000134531 MIM:602333; AllianceGenome:HGNC:3333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMP; CL-20; EMP-1
Summary
Involved in bleb assembly and cell death. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 1426.7), gall bladder (RPKM 194.7) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
12p13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (13196726..13219941)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (13071022..13094235)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13349660..13372875)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4273 Neighboring gene Sharpr-MPRA regulatory region 6445 Neighboring gene germ cell associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:13277735-13278236 Neighboring gene uncharacterized LOC124902882 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:13318180-13319379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6033 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13336996-13337496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13337497-13337997 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13351700-13352200 Neighboring gene Sharpr-MPRA regulatory region 3500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13409703-13410569 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:13417435-13418010 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:13418011-13418585 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:13492223-13493422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:13521335-13521834 Neighboring gene NANOG hESC enhancer GRCh37_chr12:13521894-13522420 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:13528282-13529481 Neighboring gene long intergenic non-protein coding RNA 1559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13591195-13591716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13591717-13592238 Neighboring gene RNA, 5S ribosomal pseudogene 353

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis. Zeng Q, et al. Cancer Med, 2023 Apr. PMID 36708070, Free PMC Article
  2. Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling. Liu S, et al. Free Radic Biol Med, 2022 Aug 20. PMID 35850179
  3. Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer. Wang Y, et al. Oxid Med Cell Longev, 2022. PMID 35432717, Free PMC Article
  4. Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma. Li X, et al. Int J Biol Markers, 2021 Sep. PMID 34569869
  5. EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis. Wang M, et al. Panminerva Med, 2020 Sep. PMID 32716150

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
    Title: Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1.
  2. Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.
    Title: Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis.
  3. Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.
    Title: Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of PPAR gamma signaling.
  4. Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.
    Title: Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer.
  5. Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
    Title: Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
  6. Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.
    Title: Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma.
  7. EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.
    Title: EMP1 promotes the malignant progression of osteosarcoma through the IRX2/MMP9 axis.
  8. Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
    Title: Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
  9. Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.
    Title: Epithelial Membrane Protein 2 Suppresses Non-Small Cell Lung Cancer Cell Growth by Inhibition of MAPK Pathway.
  10. Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.
    Title: Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bleb assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermis development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
epithelial membrane protein 1
Names
tumor-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423.3 → NP_001414.1  epithelial membrane protein 1

    See identical proteins and their annotated locations for NP_001414.1

    Status: VALIDATED

    Source sequence(s)
    AC022276, BC047300, U77085
    Consensus CDS
    CCDS8660.1
    UniProtKB/Swiss-Prot
    B2R5N1, B4DRR1, O00681, P54849, Q13481, Q13834
    Related
    ENSP00000256951.5, ENST00000256951.10
    Conserved Domains (1) summary
    pfam00822
    Location:1 → 151
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    13196726..13219941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    13071022..13094235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54849.3 GenPept UniProtKB/Swiss-Prot:P54849

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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