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Rps5 ribosomal protein S5 [ Mus musculus (house mouse) ]

Gene ID: 20103, updated on 21-Apr-2024

Summary

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Official Symbol
Rps5provided by MGI
Official Full Name
ribosomal protein S5provided by MGI
Primary source
MGI:MGI:1097682
See related
Ensembl:ENSMUSG00000012848 AllianceGenome:MGI:1097682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA binding activity and rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Predicted to be located in cytosolic ribosome. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in ribosome. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1722.8), large intestine adult (RPKM 951.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 7.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12656223..12660613)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12922311..12926686)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6510 Neighboring gene zinc finger protein 128 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13482923-13483223 Neighboring gene zinc finger and SCAN domain containing 22 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13495643-13495826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13507414-13507597 Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325 Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies. Vizirianakis IS, et al. Int J Oncol, 2015 Jul. PMID 25998414
  2. On the intracellular trafficking of mouse S5 ribosomal protein from cytoplasm to nucleoli. Matragkou Ch, et al. J Mol Biol, 2009 Oct 9. PMID 19631221
  3. The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation. Matragkou CN, et al. J Cell Biochem, 2008 Jul 1. PMID 18288641
  4. Cloning, sequencing and expression in MEL cells of a cDNA encoding the mouse ribosomal protein S5. Vanegas N, et al. Biochim Biophys Acta, 1997 Jun 5. PMID 9202169
  5. Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells. Vizirianakis IS, et al. Oncol Res, 1999. PMID 10821535

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings support the concept that genetic manipulation of RPS5 gene expression level (up- and/or downregulation) critically affects the potential of murine erythroleukemia cells to fully complete their erythroid maturation program in vitro.
    Title: Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.
  2. The results indicate that rpS5 protein enters the nucleus via the region 38-50 aa that forms a random coil as revealed by molecular dynamic simulation.
    Title: On the intracellular trafficking of mouse S5 ribosomal protein from cytoplasm to nucleoli.
  3. deregulation of RPS5 gene expression (constitutive expression) affects RPS5 protein level and delays both the onset of initiation of erythroid maturation and entrance in cell cycle arrest in inducer-treated MEL cells.
    Title: The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of translational fidelity ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein uS7
Names
40S ribosomal protein S5
S5 ribosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417226.1 → NP_001404155.1  small ribosomal subunit protein uS7

    Status: VALIDATED

    Source sequence(s)
    AC107704
    UniProtKB/Swiss-Prot
    O08607, P97461, Q91V55
    Related
    ENSMUSP00000121961.3, ENSMUST00000137329.4

  2. NM_009095.3 → NP_033121.2  small ribosomal subunit protein uS7

    See identical proteins and their annotated locations for NP_033121.2

    Status: VALIDATED

    Source sequence(s)
    AC107704
    Consensus CDS
    CCDS20817.1
    UniProtKB/Swiss-Prot
    O08607, P97461, Q91V55
    UniProtKB/TrEMBL
    D3Z1S8
    Related
    ENSMUSP00000004554.8, ENSMUST00000004554.14
    Conserved Domains (1) summary
    cd14867
    Location:18 → 204
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12656223..12660613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152810.1 → XP_036008703.1  small ribosomal subunit protein uS7 isoform X1

    UniProtKB/Swiss-Prot
    O08607, P97461, Q91V55
    UniProtKB/TrEMBL
    D3Z1S8
    Related
    ENSMUSP00000104179.2, ENSMUST00000108539.8
    Conserved Domains (1) summary
    cd14867
    Location:18 → 204
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97461.4 GenPept UniProtKB/Swiss-Prot:P97461

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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