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Rps3a1 ribosomal protein S3A1 [ Mus musculus (house mouse) ]

Gene ID: 20091, updated on 5-Mar-2024

Summary

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Official Symbol
Rps3a1provided by MGI
Official Full Name
ribosomal protein S3A1provided by MGI
Primary source
MGI:MGI:1202063
See related
Ensembl:ENSMUSG00000028081 AllianceGenome:MGI:1202063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rps3a
Summary
Predicted to enable mRNA 5'-UTR binding activity and translation initiation factor binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of fibroblast proliferation; positive regulation of translation; and translation. Predicted to act upstream of or within cell differentiation. Located in cytosol; nucleus; and synapse. Is expressed in tail. Orthologous to human RPS3A (ribosomal protein S3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 670.7), bladder adult (RPKM 656.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 37.83 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86045247..86049975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86137940..86142668, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08123 Neighboring gene STARR-seq mESC enhancer starr_08124 Neighboring gene SH3 domain protein D19 Neighboring gene serine protease 48 Neighboring gene STARR-positive B cell enhancer ABC_E9555 Neighboring gene predicted gene, 25188 Neighboring gene small nucleolar RNA, C/D box U73A Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene STARR-positive B cell enhancer ABC_E2073 Neighboring gene predicted gene, 23025 Neighboring gene LPS-responsive beige-like anchor Neighboring gene predicted gene, 26343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The S3a ribosomal protein gene is identical to the Fte-1 (v-fos transformation effector) gene and the TNF-alpha-induced TU-11 gene, and its transcript level is altered in transformed and tumor cells. Lecomte F, et al. Gene, 1997 Feb 28. PMID 9074506
  2. Nucleotide sequence and expression of ribosomal protein S3 mRNA during embryogenesis in the Mexican axolotl (Ambystoma mexicanum). Bhatia R, et al. Biochem Mol Biol Int, 1996 May. PMID 8739028
  3. Esculentoside A specifically binds to ribosomal protein S3a and impairs LPS-induced signaling in macrophages. Li YH, et al. Int Immunopharmacol, 2018 Jan. PMID 29169044
  4. Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system. De Graeve S, et al. Biochem J, 2013 Nov 1. PMID 23924367, Free PMC Article
  5. Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS. Osborne JM, et al. J Leukoc Biol, 1998 Nov. PMID 9823776

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This dysregulation is also seen in AdarDelta2-13; Mavs-/- but not in AdarE861A/E861A; Ifih1-/- mice, suggesting editing-independent functions of ADAR in regulating expression levels of Rps3a1 and Rps3a3.
    Title: An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
  2. RPS3a as an essential component for LPS-mediated pro-inflammatory signaling
    Title: Esculentoside A specifically binds to ribosomal protein S3a and impairs LPS-induced signaling in macrophages.
  3. The mouse ribosomal and chaperone protein RPS3A was identified as a suppressor of alphaSyn [WT (wild-type) and A53T] toxicity in yeast
    Title: Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102469, MGC117914

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein eS1
Names
40S ribosomal protein S3a
ribosomal protein S3A
NP_058655.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016959.4 → NP_058655.3  small ribosomal subunit protein eS1

    See identical proteins and their annotated locations for NP_058655.3

    Status: VALIDATED

    Source sequence(s)
    AI845448, AK167562, AL118161
    Consensus CDS
    CCDS17446.1
    UniProtKB/Swiss-Prot
    P97351
    UniProtKB/TrEMBL
    Q3U5P8, Q3UAC2, Q3UJU5, Q564F3, Q9D1S3
    Related
    ENSMUSP00000029722.7, ENSMUST00000029722.7
    Conserved Domains (1) summary
    pfam01015
    Location:21 → 221
    Ribosomal_S3Ae; Ribosomal S3Ae family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    86045247..86049975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97351.3 GenPept UniProtKB/Swiss-Prot:P97351

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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