Rps19 ribosomal protein S19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps19provided by MGI
Official Full Name: ribosomal protein S19provided by MGI
Primary source: MGI:MGI:1333780
See related: Ensembl:ENSMUSG00000040952 AllianceGenome:MGI:1333780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dsk3
Summary: Predicted to enable several functions, including fibroblast growth factor binding activity; identical protein binding activity; and translation initiation factor binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within Notch signaling pathway. Is active in synapse. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 234.0), liver E14.5 (RPKM 229.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.41 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24584013..24589236)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24884592..24889811)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. Results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.
Title: Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.
Rps19 mutant shows behavioural phenotypes resembling that of the human Diamond-Blackfan anaemia syndrome.
Title: Neurological Deficits of an Rps19(Arg67del) Model of Diamond-Blackfan Anaemia.
indicate the importance of the RP S19 oligomer-induced macrophage recruitment in coagulum resorption
Title: Role of blood ribosomal protein S19 in coagulum resorption: a study using Gln137Glu-ribosomal protein S19 gene knock-in mouse.
Rps19 mutant embryonic stem cells showed significant increase in p53 protein expression.
Title: p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.
We report the generation of mouse models for RPS19-deficient Diamond Blackfan anemia using transgenic RNA interference that allows an inducible and graded down-regulation of Rps19.
Title: Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
generated a transgenic model expressing an RPS19 mutation in which an arginine residue is replaced with a tryptophan residue at codon 62 as a model of Diamond-Blackfan anemia
Title: A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia.
Combined Rps19 insufficiency and Pim-1 deficiency promote murine myeloid cell growth through a deregulation of c-Myc and a simultaneous up-regulation of anti-apoptotic Bcl proteins.
Title: Cooperative effect of ribosomal protein s19 and Pim-1 kinase on murine c-Myc expression and myeloid/erythroid cellularity.
RPS19 significantly compromised CXCR2-dependent MIF-triggered adhesion of monocytes to endothelial cells under flow conditions. We, therefore, propose that RPS19 acts as an extracellular negative regulator of MIF.
Title: Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function.
Study reports two mouse dark skin (Dsk) loci caused by mutations in Rps19 (ribosomal protein S19) and Rps20 (ribosomal protein S20).
Title: Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
the loss of one Rps19 allele in mice is fully compensated for at the transcriptional level with preservation of erythropoiesis
Title: Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in maturation of SSU-rRNA	ISO Inferred from Sequence Orthology more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in nucleolus organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
part_of small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein eS19

Names: 40S ribosomal protein S19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360115.2 → NP_001347044.2 small ribosomal subunit protein eS19 isoform a

Status: VALIDATED

Source sequence(s)

AC161441

UniProtKB/Swiss-Prot

Q5M9J4, Q9CZX8
NM_001360116.2 → NP_001347045.1 small ribosomal subunit protein eS19 isoform b

Status: VALIDATED

Source sequence(s)

AC161441

UniProtKB/TrEMBL

Q5M9P3

Related

ENSMUSP00000120774.2, ENSMUST00000156372.8

Conserved Domains (1) summary

pfam01090
Location:16 → 152

Ribosomal_S19e; Ribosomal protein S19e
NM_001360118.2 → NP_001347047.1 small ribosomal subunit protein eS19 isoform a

Status: VALIDATED

Source sequence(s)

AC161441

Consensus CDS

CCDS20966.1

UniProtKB/Swiss-Prot

Q5M9J4, Q9CZX8

UniProtKB/TrEMBL

Q5M9P3

Related

ENSMUSP00000114949.3, ENSMUST00000153451.9

Conserved Domains (1) summary

pfam01090
Location:5 → 141

Ribosomal_S19e; Ribosomal protein S19e
NM_001360119.2 → NP_001347048.1 small ribosomal subunit protein eS19 isoform a

Status: VALIDATED

Source sequence(s)

AC161441

Consensus CDS

CCDS20966.1

UniProtKB/Swiss-Prot

Q5M9J4, Q9CZX8

UniProtKB/TrEMBL

Q5M9P3

Related

ENSMUSP00000104068.4, ENSMUST00000108430.10

Conserved Domains (1) summary

pfam01090
Location:5 → 141

Ribosomal_S19e; Ribosomal protein S19e
NM_001360125.2 → NP_001347054.1 small ribosomal subunit protein eS19 isoform d

Status: VALIDATED

Source sequence(s)

AC161441

UniProtKB/TrEMBL

Q5M9P3

Conserved Domains (1) summary

pfam01090
Location:5 → 131

Ribosomal_S19e; Ribosomal protein S19e
NM_001360128.2 → NP_001347057.1 small ribosomal subunit protein eS19 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC161441

Conserved Domains (1) summary

cl00969
Location:5 → 71

Ribosomal_S19e; Ribosomal protein S19e
NM_023133.2 → NP_075622.1 small ribosomal subunit protein eS19 isoform a

See identical proteins and their annotated locations for NP_075622.1

Status: VALIDATED

Source sequence(s)

AC161441

Consensus CDS

CCDS20966.1

UniProtKB/Swiss-Prot

Q5M9J4, Q9CZX8

UniProtKB/TrEMBL

Q5M9P3

Related

ENSMUSP00000104067.2, ENSMUST00000108429.8

Conserved Domains (1) summary

pfam01090
Location:5 → 141

Ribosomal_S19e; Ribosomal protein S19e

RNA

NR_153408.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC161441

Related

ENSMUST00000129847.8
NR_153409.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC161441