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TIGD1 tigger transposable element derived 1 [ Homo sapiens (human) ]

Gene ID: 200765, updated on 5-Mar-2024

Summary

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Official Symbol
TIGD1provided by HGNC
Official Full Name
tigger transposable element derived 1provided by HGNC
Primary source
HGNC:HGNC:14523
See related
Ensembl:ENSG00000221944 MIM:612972; AllianceGenome:HGNC:14523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EEYORE
Summary
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See TIGD1 in Genome Data Viewer
Location:
2q37.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (232543883..232550557, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (233030667..233037341, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233408593..233415267, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233388351-233388860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233390966-233391619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233398312-233398832 Neighboring gene serine protease 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233399875-233400394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17323 Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12460 Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene microRNA 5001 Neighboring gene eukaryotic translation initiation factor 4E family member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:233432608-233433807 Neighboring gene uncharacterized LOC105373929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233465129-233465628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17325 Neighboring gene EF-hand domain family member D1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12461 Neighboring gene Sharpr-MPRA regulatory region 9991 Neighboring gene RNA, 7SL, cytoplasmic 359, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer. Yin L, et al. J Cell Biochem, 2019 Jun. PMID 30548305
  2. Members of the pogo superfamily of DNA-mediated transposons in the human genome. Robertson HM. Mol Gen Genet, 1996 Oct 28. PMID 8917322
  3. Tiggers and DNA transposon fossils in the human genome. Smit AF, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643651, Free PMC Article
  4. F-box only protein 9 is an E3 ubiquitin ligase of PPARγ. Lee KW, et al. Exp Mol Med, 2016 May 20. PMID 27197753, Free PMC Article
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression.
    Title: Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression.
  2. inding provides evidence that TIGD1 involve in the cell cycle. These findings provide fresh insight into our understanding of TEs in cancers. Next, the detailed mechanism of TIGD1 needs to be studied in the future.
    Title: TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tigger transposable element-derived protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145702.4 → NP_663748.1  tigger transposable element-derived protein 1

    See identical proteins and their annotated locations for NP_663748.1

    Status: VALIDATED

    Source sequence(s)
    AC092165
    Consensus CDS
    CCDS2495.1
    UniProtKB/Swiss-Prot
    Q6P4D2, Q6PIF9, Q96MW7
    Related
    ENSP00000386186.3, ENST00000408957.7
    Conserved Domains (3) summary
    smart00674
    Location:76 → 149
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:216 → 403
    DDE_1; DDE superfamily endonuclease
    pfam04218
    Location:9 → 60
    CENP-B_N; CENP-B N-terminal DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    232543883..232550557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    233030667..233037341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MW7.1 GenPept UniProtKB/Swiss-Prot:Q96MW7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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