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TMEM61 transmembrane protein 61 [ Homo sapiens (human) ]

Gene ID: 199964, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM61provided by HGNC
Official Full Name
transmembrane protein 61provided by HGNC
Primary source
HGNC:HGNC:27296
See related
Ensembl:ENSG00000143001 AllianceGenome:HGNC:27296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 2.4) and 12 other tissues See more
Orthologs
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Genomic context

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See TMEM61 in Genome Data Viewer
Location:
1p32.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54980628..54992288)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54860835..54872524)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55446301..55457961)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904184 Neighboring gene tRNA-Lys (anticodon CTT) 7-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1069 Neighboring gene uncharacterized LOC105378736 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55462851-55463835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55466287-55466787 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55484247-55484747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55488329-55488955 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493259-55493762 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493763-55494266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55494267-55494770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:55501658-55501847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509121-55509622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509623-55510122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55514655-55515210 Neighboring gene proprotein convertase subtilisin/kexin type 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article
  2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182532.3 → NP_872338.1  transmembrane protein 61

    See identical proteins and their annotated locations for NP_872338.1

    Status: VALIDATED

    Source sequence(s)
    AA918832, AL590440, BC029775, BG430102
    Consensus CDS
    CCDS601.1
    UniProtKB/Swiss-Prot
    Q8N0U2
    Related
    ENSP00000360315.3, ENST00000371268.4
    Conserved Domains (1) summary
    pfam15105
    Location:13 → 206
    TMEM61; TMEM61 protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54980628..54992288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540911.3 → XP_011539213.1  transmembrane protein 61 isoform X1

    See identical proteins and their annotated locations for XP_011539213.1

    UniProtKB/Swiss-Prot
    Q8N0U2
    Conserved Domains (1) summary
    pfam15105
    Location:13 → 206
    TMEM61; TMEM61 protein family

  2. XM_005270586.5 → XP_005270643.1  transmembrane protein 61 isoform X2

    See identical proteins and their annotated locations for XP_005270643.1

    Conserved Domains (1) summary
    pfam15105
    Location:8 → 201
    TMEM61; TMEM61 protein family

  3. XM_011540912.3 → XP_011539214.1  transmembrane protein 61 isoform X2

    See identical proteins and their annotated locations for XP_011539214.1

    Conserved Domains (1) summary
    pfam15105
    Location:8 → 201
    TMEM61; TMEM61 protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54860835..54872524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334900.1 → XP_054190875.1  transmembrane protein 61 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0U2

  2. XM_054334901.1 → XP_054190876.1  transmembrane protein 61 isoform X2

  3. XM_054334902.1 → XP_054190877.1  transmembrane protein 61 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N0U2.1 GenPept UniProtKB/Swiss-Prot:Q8N0U2

Gene LinkOut

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