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Rpl6 ribosomal protein L6 [ Mus musculus (house mouse) ]

Gene ID: 19988, updated on 3-Apr-2024

Summary

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Official Symbol
Rpl6provided by MGI
Official Full Name
ribosomal protein L6provided by MGI
Primary source
MGI:MGI:108057
See related
Ensembl:ENSMUSG00000029614 AllianceGenome:MGI:108057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Taxreb107
Summary
Predicted to enable 5.8S rRNA binding activity; mRNA binding activity; and tRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Located in postsynaptic density. Is expressed in several structures, including genitourinary system; intestine; liver; lung; and spleen. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 369.7), CNS E11.5 (RPKM 369.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 61.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121342564..121347304)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121204501..121209241)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32185 Neighboring gene rabphilin 3A Neighboring gene STARR-positive B cell enhancer ABC_E3611 Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671 Neighboring gene predicted gene, 42020 Neighboring gene TRAF type zinc finger domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells. Wittlin S, et al. Biochim Biophys Acta, 2003 Oct 21. PMID 14572897
  2. The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions. Nacken W, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7537974
  3. Isolation and characterization of chicken TaxREB107, a putative DNA binding protein abundantly expressed in muscle. Thomson SR, et al. Gene, 2001 Oct 31. PMID 11707324
  4. Identification and verification of novel rodent postsynaptic density proteins. Jordan BA, et al. Mol Cell Proteomics, 2004 Sep. PMID 15169875
  5. Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Wang J, et al. Biochim Biophys Acta, 2002 Jun 7. PMID 12031506

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taxreb107 has a role as a lactogenic hormone-responsive gene during differentiation of the mammary gland.
    Title: Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117949

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5.8S rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL6
Names
60S ribosomal protein L6
TAX-responsive enhancer element-binding protein 107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421310.1 → NP_001408239.1  large ribosomal subunit protein eL6

    Status: VALIDATED

    Source sequence(s)
    AC110037
    UniProtKB/Swiss-Prot
    P47911, Q6P5I2, Q925C3
    UniProtKB/TrEMBL
    Q3UCH0

  2. NM_011290.5 → NP_035420.2  large ribosomal subunit protein eL6

    See identical proteins and their annotated locations for NP_035420.2

    Status: VALIDATED

    Source sequence(s)
    AK151022, AK153208, CJ316043
    Consensus CDS
    CCDS19632.1
    UniProtKB/Swiss-Prot
    P47911, Q6P5I2, Q925C3
    UniProtKB/TrEMBL
    Q3UCH0, Q3UFI4
    Related
    ENSMUSP00000031617.10, ENSMUST00000031617.13
    Conserved Domains (2) summary
    cd13156
    Location:144 → 296
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:50 → 103
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121342564..121347304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47911.3 GenPept UniProtKB/Swiss-Prot:P47911

Gene LinkOut

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