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Rpl22 ribosomal protein L22 [ Mus musculus (house mouse) ]

Gene ID: 19934, updated on 16-Apr-2024

Summary

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Official Symbol
Rpl22provided by MGI
Official Full Name
ribosomal protein L22provided by MGI
Primary source
MGI:MGI:99262
See related
Ensembl:ENSMUSG00000028936 AllianceGenome:MGI:99262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700038K18Rik
Summary
Enables heparin binding activity and translation regulator activity. Involved in regulation of translation at presynapse, modulating synaptic transmission. Acts upstream of or within alpha-beta T cell differentiation. Located in glutamatergic synapse; presynapse; and ribosome. Orthologous to human RPL22 (ribosomal protein L22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 82.1), bladder adult (RPKM 62.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 83.03 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152408893..152418539)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152324436..152334082)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207 Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, beta member 2 Neighboring gene predicted gene 16333

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes. Mazumder AG, et al. iScience, 2022 Dec 22. PMID 36465110, Free PMC Article
  2. A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis. Baur K, et al. EMBO Rep, 2022 Sep 5. PMID 35861333, Free PMC Article
  3. Hippocampal neurons' cytosolic and membrane-bound ribosomal transcript profiles are differentially regulated by learning and subsequent sleep. Delorme J, et al. Proc Natl Acad Sci U S A, 2021 Nov 30. PMID 34819370, Free PMC Article
  4. Estrogen Regulation of the Molecular Phenotype and Active Translatome of AVPV Kisspeptin Neurons. Stephens SBZ, et al. Endocrinology, 2021 Sep 1. PMID 33856454, Free PMC Article
  5. The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins. Liakath-Ali K, et al. Front Mol Neurosci, 2021. PMID 33767611, Free PMC Article

See all (225) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
    Title: RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
  2. Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis.
    Title: Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
  3. finding that Rpl22 deficiency exacerbates endoplasmic reticulum stress responses and induces p53 in alphabeta T cell progenitors provides insight into how a ubiquitously expressed RP can perform regulatory functions that are selectively required by some cell lineages but not others
    Title: Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.
  4. RPL22 underexpression is associated with Dissemination of T-cell Lymphoma.
    Title: Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.
  5. Rpl22 performs a critical, developmentally restricted role in supporting early B cell development by preventing p53 induction.
    Title: Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.
  6. either ribosomal protein can support translation, knockdown of Rpl22l1 impairs growth of cells lacking Rpl22. Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an internal hairpin structure and repressing its expression
    Title: The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.
  7. Rpl22 inactivation promotes neoplastic transformation by inducing expression of Lin28B
    Title: Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
  8. Investigation of downstream effectors used by tumor protein p53 to impair T cell lineage development finds many p53 targets are induced in Rpl22-deficient thymocytes, including miR-34a, PUMA, p21waf, Bax, and Noxa.
    Title: Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors.
  9. Rpl22 deficiency activated a p53-dependent checkpoint that produced a remarkably selective block in alphabeta T cell development.
    Title: Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation at presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL22
Names
60S ribosomal protein L22
heparin-binding protein HBp15
NP_001264042.1
NP_001264043.1
NP_033105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277113.1 → NP_001264042.1  large ribosomal subunit protein eL22 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Conserved Domains (1) summary
    pfam01776
    Location:39 → 142
    Ribosomal_L22e; Ribosomal L22e protein family

  2. NM_001277114.2 → NP_001264043.1  large ribosomal subunit protein eL22 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Conserved Domains (1) summary
    pfam01776
    Location:16 → 80
    Ribosomal_L22e; Ribosomal L22e protein family

  3. NM_009079.4 → NP_033105.1  large ribosomal subunit protein eL22 isoform a

    See identical proteins and their annotated locations for NP_033105.1

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS18999.1
    UniProtKB/Swiss-Prot
    P67984
    UniProtKB/TrEMBL
    Q4VAG4
    Related
    ENSMUSP00000118787.2, ENSMUST00000139685.8
    Conserved Domains (1) summary
    pfam01776
    Location:21 → 119
    Ribosomal_L22e; Ribosomal L22e protein family

RNA

  1. NR_102291.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611985

  2. NR_102292.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611985

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152408893..152418539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P67984.2 GenPept UniProtKB/Swiss-Prot:P67984

Gene LinkOut

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