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Rpl19 ribosomal protein L19 [ Mus musculus (house mouse) ]

Gene ID: 19921, updated on 11-Apr-2024

Summary

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Official Symbol
Rpl19provided by MGI
Official Full Name
ribosomal protein L19provided by MGI
Primary source
MGI:MGI:98020
See related
Ensembl:ENSMUSG00000017404 AllianceGenome:MGI:98020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to act upstream of or within translation. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in cumulus oophorus; early conceptus; oocyte; and ovary. Orthologous to human RPL19 (ribosomal protein L19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 435.4), placenta adult (RPKM 390.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.56 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97912829..97921319)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98022003..98030493)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of mouse L19 ribosomal protein cDNA isolated in screening with tre oncogene probes. Nakamura T, et al. DNA Cell Biol, 1990 Dec. PMID 1702292
  2. Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies. Czabanka M, et al. Eur J Cancer, 2011 May. PMID 21396810
  3. Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation. Smith SE, et al. Dev Biol, 1997 Apr 1. PMID 9142982
  4. Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development. Hou Q, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415723, Free PMC Article
  5. The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. Wagner K, et al. Clin Cancer Res, 2008 Aug 1. PMID 18676770

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. L19-SIP shows a time and blood-flow dependent microvascular biodistribution process with angiogenic sprouts as preferential binding sites followed by secondary extravasation of the antibody
    Title: Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies.
  2. L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer
    Title: The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5.8S rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables large ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL19
Names
60S ribosomal protein L19
NP_001152955.1
NP_033104.2
XP_006532673.1
XP_030101565.1
XP_036012353.1
XP_036012354.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159483.1 → NP_001152955.1  large ribosomal subunit protein eL19 isoform 2

    See identical proteins and their annotated locations for NP_001152955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' exon and uses a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AV467392, CB203522
    Consensus CDS
    CCDS48900.1
    UniProtKB/TrEMBL
    A2A547
    Related
    ENSMUSP00000103181.2, ENSMUST00000092425.11
    Conserved Domains (1) summary
    cd01417
    Location:2 → 165
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

  2. NM_009078.2 → NP_033104.2  large ribosomal subunit protein eL19 isoform 1

    See identical proteins and their annotated locations for NP_033104.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AV467392, BC089549, BU524941
    Consensus CDS
    CCDS25337.1
    UniProtKB/Swiss-Prot
    P84099
    UniProtKB/TrEMBL
    Q5I0T8
    Related
    ENSMUSP00000017548.7, ENSMUST00000017548.7
    Conserved Domains (1) summary
    cd01417
    Location:4 → 167
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97912829..97921319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532610.4 → XP_006532673.1  large ribosomal subunit protein eL19 isoform X2

    See identical proteins and their annotated locations for XP_006532673.1

    UniProtKB/TrEMBL
    A2A547
    Conserved Domains (1) summary
    cd01417
    Location:2 → 165
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

  2. XM_030245705.1 → XP_030101565.1  large ribosomal subunit protein eL19 isoform X2

    UniProtKB/TrEMBL
    A2A547
    Conserved Domains (1) summary
    cd01417
    Location:2 → 165
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

  3. XM_036156460.1 → XP_036012353.1  large ribosomal subunit protein eL19 isoform X1

    UniProtKB/Swiss-Prot
    P84099
    UniProtKB/TrEMBL
    Q5I0T8
    Conserved Domains (1) summary
    cd01417
    Location:4 → 167
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...

  4. XM_036156461.1 → XP_036012354.1  large ribosomal subunit protein eL19 isoform X1

    UniProtKB/Swiss-Prot
    P84099
    UniProtKB/TrEMBL
    Q5I0T8
    Conserved Domains (1) summary
    cd01417
    Location:4 → 167
    Ribosomal_L19e_E; Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84099.1 GenPept UniProtKB/Swiss-Prot:P84099

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