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Rpl18 ribosomal protein L18 [ Mus musculus (house mouse) ]

Gene ID: 19899, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl18provided by MGI
Official Full Name
ribosomal protein L18provided by MGI
Primary source
MGI:MGI:98003
See related
Ensembl:ENSMUSG00000059070 AllianceGenome:MGI:98003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L18; Rpl18a
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in endoplasmic reticulum; nucleolus; and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in brain. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 264.4), large intestine adult (RPKM 246.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl18 in Genome Data Viewer
Location:
7 B3; 7 29.45 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45364891..45370255)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45715467..45720835)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene sphingosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52988906-52989102 Neighboring gene sulfotransferase family, cytosolic, 2B, member 1 Neighboring gene predicted gene, 31597 Neighboring gene STARR-seq mESC enhancer starr_18855

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of four mouse ribosomal-protein-L18 genes that appear to be processed pseudogenes. Peled-Yalif E, et al. Gene, 1984 Jul-Aug. PMID 6149171
  2. Gene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene. Molina A, et al. Biochim Biophys Acta, 2001 Sep 21. PMID 11566355
  3. Sequence analysis of mouse cDNAs encoding ribosomal proteins L12 and L18. Hou EW, et al. Gene, 1993 Aug 25. PMID 8359697
  4. Transcriptional and translational regulation of ribosomal protein formation during mouse myoblast differentiation. Agrawal MG, et al. J Biol Chem, 1987 Apr 5. PMID 3558374
  5. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL18
Names
60S ribosomal protein L18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417207.1 → NP_001404136.1  large ribosomal subunit protein eL18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167242

  2. NM_009077.3 → NP_033103.2  large ribosomal subunit protein eL18 isoform 1

    See identical proteins and their annotated locations for NP_033103.2

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS39958.1
    UniProtKB/Swiss-Prot
    P35980, Q9CQF1, Q9D987
    UniProtKB/TrEMBL
    Q58EW0, Q642K1
    Related
    ENSMUSP00000072320.7, ENSMUST00000072503.13
    Conserved Domains (1) summary
    pfam17135
    Location:2 → 176
    Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45364891..45370255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242247.1 → XP_030098107.1  large ribosomal subunit protein eL18 isoform X1

    UniProtKB/Swiss-Prot
    P35980, Q9CQF1, Q9D987
    UniProtKB/TrEMBL
    Q58EW0, Q642K1
    Related
    ENSMUSP00000147816.2, ENSMUST00000210640.2
    Conserved Domains (1) summary
    pfam17135
    Location:2 → 176
    Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

  2. XM_017322049.3 → XP_017177538.1  large ribosomal subunit protein eL18 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GQU8, A0A1B0GSF7
    Related
    ENSMUSP00000147918.2, ENSMUST00000209287.2
    Conserved Domains (1) summary
    pfam17135
    Location:1 → 136
    Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35980.3 GenPept UniProtKB/Swiss-Prot:P35980

Gene LinkOut

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