Ros1 Ros1 proto-oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ros1provided by MGI
Official Full Name: Ros1 proto-oncogeneprovided by MGI
Primary source: MGI:MGI:97999
See related: Ensembl:ENSMUSG00000019893 AllianceGenome:MGI:97999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ros-1; c-ros
Summary: Enables protein phosphatase binding activity. Involved in several processes, including columnar/cuboidal epithelial cell development; regulation of ERK1 and ERK2 cascade; and spermatogenesis. Acts upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Located in cell surface and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; intestine; lung; stomach; and trunk. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 7.5) See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 26.18 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (51920959..52071494, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (52044863..52195398, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPX1-dependent alterations in oxido-reductive stress promote ROS1 activation and mediate vascular remodeling.
Title: Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.
Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.
Title: Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.
c-ros and its ligand may be necessary for differentiation of epithelia I and II in mouse.
Title: Development of the caput epididymidis studied by expressed proteins (a glutamate transporter, a lipocalin and beta-galactosidase) in the c-ros knockout and wild-type mice with prepubertally ligated efferent ducts.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

D10Mit56 (e-PCR), detects polymorphism
- UniSTS:126237

Ros1 (e-PCR), detects polymorphism
- UniSTS:517759

D10Mit256 (e-PCR), detects polymorphism
- UniSTS:116611

X81650 (e-PCR)
- UniSTS:125867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in columnar/cuboidal epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase ROS

Names: c-Ros receptor tyrosine kinase; c-ros-1; proto-oncogene c-Ros; proto-oncogene c-Ros-1; receptor tyrosine kinase c-ros oncogene 1

NP_035412.2

EC 2.7.10.1

XP_011241449.1

EC 2.7.10.1

XP_017169344.1

EC 2.7.10.1

XP_017169345.1

EC 2.7.10.1

XP_017169346.1

EC 2.7.10.1

XP_017169347.1

EC 2.7.10.1

XP_017169348.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011282.2 → NP_035412.2 proto-oncogene tyrosine-protein kinase ROS precursor

See identical proteins and their annotated locations for NP_035412.2

Status: VALIDATED

Source sequence(s)

AC153950, AC155831

Consensus CDS

CCDS23838.1

UniProtKB/Swiss-Prot

Q60705, Q78DX7

UniProtKB/TrEMBL

A0A1W2P7L6

Related

ENSMUSP00000020045.4, ENSMUST00000020045.10

Conserved Domains (4) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1948 → 2209

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

pfam07714
Location:1948 → 2208

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

51920959..52071494 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313858.1 → XP_017169347.1 proto-oncogene tyrosine-protein kinase ROS isoform X5

UniProtKB/TrEMBL

A0A1W2P7L6

Conserved Domains (2) summary

cd00063
Location:19 → 103

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1761 → 2022

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_017313855.1 → XP_017169344.1 proto-oncogene tyrosine-protein kinase ROS isoform X2

UniProtKB/TrEMBL

A0A1W2P7L6

Conserved Domains (3) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1823 → 2084

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_011243147.2 → XP_011241449.1 proto-oncogene tyrosine-protein kinase ROS isoform X1

UniProtKB/TrEMBL

A0A1W2P7L6

Conserved Domains (3) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05044
Location:1949 → 2210

PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
XM_017313856.1 → XP_017169345.1 proto-oncogene tyrosine-protein kinase ROS isoform X3

UniProtKB/TrEMBL

A0A1W2P7L6

Related

ENSMUSP00000151615.2, ENSMUST00000219173.2

Conserved Domains (3) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21453
Location:1949 → 2184

PKc_like; Protein Kinases, catalytic domain
XM_017313857.2 → XP_017169346.1 proto-oncogene tyrosine-protein kinase ROS isoform X4

UniProtKB/TrEMBL

A0A1W2P7L6

Conserved Domains (3) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21453
Location:1949 → 2144

PKc_like; Protein Kinases, catalytic domain
XM_017313859.1 → XP_017169348.1 proto-oncogene tyrosine-protein kinase ROS isoform X6

Conserved Domains (2) summary

smart00060
Location:112 → 179

FN3; Fibronectin type 3 domain

cd00063
Location:207 → 291

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...